Stroke

From SNPedia

Stroke, also known clinically as a cerebrovascular accident, is defined as a disturbance in the flow of blood to the brain and the consequent loss of brain function. It is one of the leading causes of death worldwide; more information is available at Wikipedia.

SNPs affecting the risk of one or more types of stroke include the following:

• rs1401296, in the PROC gene
• rs6025, known as F5 Leiden
• rs3030341
• rs6797312, in the SERPIN1 gene
• rs5443, in the GNB3 gene
• rs173686, in the CSPG2 gene, linked to intracranial aneurysm

One or more SNPs in the following genes have also been linked to stroke risk:

• PDE4D
• APOE

In Asian patients, two SNPs in the PRKCH gene have been linked to cerebral infarctions:

• rs2230500, also known as 1425G/A
• rs3783799, also known as SNP_15

Note that there are two common forms of strokes, hemorrhagic and ischemic. Basically, ischemic strokes result from a blockage, whereas hemorrhagic result from the bursting of an aneurysmal artery in the brain (and consequent loss of blood and pressure to the brain). SNPs associated with increased risk for aneurysms are therefore potentially associated with hemorrhagic stroke risk.