From SNPedia
rs12425791 is one of 2 SNPs found near the
NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic
stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is
rs11833579.
Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. [PMID 19369658]
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| PharmGKB | PA164738465 |
| Name | |
| Annotation | This variant within 11 kb of the gene NINJ2 were associated with an increased risk of total (i.e., all types) and ischemic stroke. NINJ2 encodes an adhesion molecule expressed in glia and shows increased expression after nerve injury. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:19369658 |
| Drugs | |
| Diseases | Stroke |
| Curation Level | Curated |
