From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
|
possibly increased risk of stroke
|
| (A;G)
|
|
mixed evidence of increased risk for stroke
|
| (G;G)
|
0
|
normal
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
is one of 2 SNPs found near the
NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic
stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is
rs11833579.
Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. [PMID 19369658]
Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either rs12425791 or rs11833579 and ischemic (or incident) stroke.[1]
| PharmGKB | PA164739855 |
| Name | |
| Annotation | GWAS results: Genomewide Association Studies of Stroke. (Initial Sample Size: 19,602 Caucasian individuals; Replication Sample Size: 3,004 African American individuals, 652 Caucasian cases, 3,613 Caucasian controls); (Region: 12p13.33; Reported Gene(s): NINJ2; Risk Allele: rs12425791-A); (p-value= 0.000000001).This variant is associated with Stroke. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:19369658; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Stroke |
| Curation Level | Non-Curated |
| PharmGKB | PA164738465 |
| Name | |
| Annotation | This variant within 11 kb of the gene NINJ2 were associated with an increased risk of total (i.e., all types) and ischemic stroke. NINJ2 encodes an adhesion molecule expressed in glia and shows increased expression after nerve injury. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:19369658 |
| Drugs | |
| Diseases | Stroke |
| Curation Level | Curated |
[PMID 21722921] NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
[PMID 21832970] Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population
[PMID 22011019] Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia
[PMID 22212150] Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan
[PMID 22429733] NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions
