Rs2230500

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is asnp
is mentioned by
dbSNPrs2230500
hapmaprs2230500
hgdprs2230500
ensemblrs2230500
gopubmedrs2230500
scholarrs2230500
googlers2230500
pharmgkbrs2230500
hgvbaseg2prs2230500
medrefsnprs2230500
23andMers2230500
SNP Nexus

GenePRKCH
Chromosome14
Orientationplus
Position60993991
GenotypeEffect
rs2230500(A;A)1.4x increased risk for stroke
rs2230500(A;G)1.4x increased risk for stroke
rs2230500(G;G)normal risk


Genotypes Magnitude Summary
Rs2230500(A;A) 1.4x increased risk for stroke
Rs2230500(A;G) 1.4x increased risk for stroke
Rs2230500(G;G) 00 normal risk
A common SNP only in Asian populations, this SNP (also known as 1425G/A) and a close neighbor also in the PRKCH gene, rs3783799, have been associated with higher risk for subcortical silent brain infarction, a common form of stroke.

In one study of ~1100 Japanese stroke patients, the odds ratio for carriers of the rs2230500(A) risk allele was reported as 1.40 (CI: 1.23-1.59, p=5x10e-7).[PMID 17206144]

A subsequent study reported the odds ratio for carriers of the (A) allele as 1.27 (CI: 1.09-1.48, p=0.0026) compared to individuals homozygous for rs2230500(G), based on studies of ~300 Japanese patients. [PMID 18164711]

[PMID 19069168] rs2230500 (V374I) and rs9943582 were significantly associated with stroke

? (G;G)


[PMID 19520989] The 1425G/A SNP in PRKCH Is Associated With Ischemic Stroke and Cerebral Hemorrhage in a Chinese Population

Related to PROTEIN KINASE C, ETA; PRKCH according to omim 605437. See also
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