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Magnitude

From SNPedia

See also Max Magnitude, Genotype, Genoset and Repute and Promethease/Learn_More

Magnitude is a subjective measure of interest. Over time it should be adjusted up or down by the community. It is generally interpreted as follows...

0 You have the common genotype, for which nothing interesting is known.
0.1 You have the common genotype, but its interesting that this varies for others
1 Semi-plausible but not very exciting
(blank) No one has yet assigned a magnitude. Treated as a 1.
2 looks interesting enough to be worth reading
2.1 hmm, interesting
3 Probably worth your time
10 Really significant information!

Numbers bigger than 10 are allowed and expected in the future. Since User:Watson and User:Steven Pinker requested not to learn their APOE4 gs216 status that serves as useful a landmark in the scale. Several rare genotypes are higher magnitude. The genotypes with highest magnitude are

 MagnitudeReputeSummary
i4000378(I;I)10BadBRCA1 (breast cancer) 5382insC
rs137852689(C;C)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894086(A;A)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs387907235(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894090(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894086(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs137852690(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894085(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894087(A;A)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs193922393(-;-)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
... further results

The genosets with the highest magnitude are

 MagnitudeReputeSummary
Gs14910Testing for orientation issues
Gs3007Data Quality issue. Your data provider is reporting heterozygosity on the Y chromosome.
Gs3037WeGene quality control issues.
Gs3066.5BadPoor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur).
Gs2676APOE1/APOE1
Gs2166Bad2 copies of the APOE-ε4 allele
Gs2286BadSickle cell affected
Gs3125.5BadIntermediate metabolizer of fluoropyrimidines (such as 5-fluorouracil and capecitabine).
Gs1215BadDR3/4-DQ8 individual at high risk for type-1 diabetes
Gs3055BadLikely carrier of one PiS and one PiZ Alpha-1 Antitrypsin (SERPINA1) alleles; A1AT deficiency
... further results

See also the related concept Repute.