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From SNPedia

See also Max Magnitude, Genotype, Genoset and Repute and Promethease/Learn_More

Magnitude is a subjective measure of interest. Over time it should be adjusted up or down by the community. It is generally interpreted as follows...

0 You have the common genotype, for which nothing interesting is known.
0.1 You have the common genotype, but its interesting that this varies for others
1 Semi-plausible but not very exciting
(blank) No one has yet assigned a magnitude. Treated as a 1.
2 looks interesting enough to be worth reading
2.1 hmm, interesting
3 Probably worth your time
10 Really significant information!

Numbers bigger than 10 are allowed and expected in the future. Since User:Watson and User:Steven Pinker requested not to learn their APOE4 gs216 status that serves as useful a landmark in the scale. Several rare genotypes are higher magnitude. The genotypes with highest magnitude are

i4000378(I;I)10BadBRCA1 (breast cancer) 5382insC
rs751037529(G;G)9BadEarly-onset (juvenile) Parkinson's disease likely
rs34424986(T;T)9BadEarly-onset (juvenile) Parkinson's disease likely
rs137853060(T;T)9BadEarly-onset (juvenile) Parkinson's disease likely
rs397518439(T;T)9BadEarly-onset (juvenile) Parkinson's disease likely
rs137853054(G;G)9BadEarly-onset (juvenile) Parkinson's disease likely
rs137853055(T;T)9BadEarly-onset (juvenile) Parkinson's disease likely
rs137853056(A;A)9BadEarly-onset (juvenile) Parkinson's disease likely
rs137853057(T;T)9BadEarly-onset (juvenile) Parkinson's disease likely
rs137853058(A;A)9BadEarly-onset (juvenile) Parkinson's disease likely
... further results

The genosets with the highest magnitude are

Gs14910testing for orientation issues
Gs3037WeGene quality control issues.
Gs3007Data Quality issue. Your data provider is reporting heterozygosity on the Y chromosome.
Gs2286Badsickle cell affected
Gs2166Bad2 copies of the APOE-ε4 allele
Gs1215BadDR3/4-DQ8 individual at high risk for type-1 diabetes
Gs2615Did you mix multiple people together?
Gs2665Data Quality Warning
Gs2544.1BadPseudocholinesterase Deficiency
... further results

See also the related concept Repute.