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From SNPedia
Magnitude 5.5
Repute Bad
Summary ~6x higher risk for end-stage renal disease
Criteria Gs329/criteria

This genoset represent someone (usually someone of African ancestry) carrying one G1 and one G2 allele of the APOL1 gene, which together increases risk for kidney disease about 6 fold; this is of potential clinical significance both to the individual as well as for kidney transplantation considerations. More details can be found through the links for rs73885319 and rs71785313.