|| Normal risk of developing restless legs syndrome
|| >1.7x risk for developing restless legs syndrome
|| 1.7x risk for developing restless legs syndrome
|?|| (G;G) (G;T) (T;T) ||28|
, a SNP located in the MEIS1
gene, has been linked to restless legs syndrome
, a common sleep disorder, with an overall odds ratio of 1.78 (CI: 1.52-2.09) for the (G) risk allele [PMID 17637780
]. The association between this SNP and RLS has been replicated in three European populations, within family lines but not in sporadic cases [PMID 19279021
The highest association to restless legs syndrome is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41) [PMID 17637780].
Variants in MEIS1 rs2300478, BTBD9 rs9357271, and MAP2K5/SKOR1 rs1026732 confer a significant risk of RLS in a US population. [PMID 21925394]
In another study, rs2300478 was not associated with attention deficit hyperactivity disorder (ADHD). [PMID 19223043]
[PMID 19223043] Exploring the genetic link between RLS and ADHD
|| [PMID 21779176]
|| Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
| Risk Allele
| Odds Ratio
|| 1.6800 [1.57-1.81]
[PMID 21925394] Association studies of variants in MEIS1, BTBD9, and MAP2K5/SKOR1 with restless legs syndrome in a US population.
[PMID 19126776] MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.
|| Insufficiently evaluated pathogenic
Restless Legs Syndrome: Preliminary Research
[PMID 26643377] Susceptible genes of restless legs syndrome in migraine.
[PMID 26703954] Prevalence and determinants of periodic limb movements in the general population.