Rs12469063

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is asnp
is mentioned by
dbSNPrs12469063
hapmaprs12469063
hgdprs12469063
ensemblrs12469063
gopubmedrs12469063
scholarrs12469063
googlers12469063
pharmgkbrs12469063
hgvbaseg2prs12469063
medrefsnprs12469063
23andMers12469063
SNP Nexus

GeneMEIS1
Chromosome2
Orientationplus
Position66617811
GenotypeEffect
rs12469063(A;A)>1.7x risk for restless legs
rs12469063(A;G)1.7x risk for restless legs
rs12469063(G;G)common


Genotypes Magnitude Summary
Rs12469063(A;A) 00 >1.7x risk for restless legs
Rs12469063(A;G) 1.7x risk for restless legs
Rs12469063(G;G) common
rs12469063, a SNP located in the MEIS1 gene, has been linked to restless legs syndrome, a common sleep disorder, with an overall odds ratio of 1.78 (CI: 1.52-2.10) for the (G) risk allele. [PMID 17637780]

The association from this region that gives the highest association to restless legs syndrome, however, is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). [PMID 17637780]

? (A;A) (A;G) (G;G)


[PMID 19223043] Exploring the genetic link between RLS and ADHD

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