|(C;C)||2.5||adults likely to be 0.44 BMI units higher|
|(C;T)||2||adults likely to be 0.22 BMI units higher|
[PMID 18697794] The rs17782313(C) allele is significantly associated with higher intakes of total energy and dietary fat. In addition, the SNP was related to greater long-term weight change and increased risk of diabetes in women.
|Condition||Body mass index|
|95% CI||0.04-0.06) unit increase in log(BMI|
[PMID 19265794] Investigation of the Locus Near MC4R With Childhood Obesity in Americans of European and African Ancestry
|Title||Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations|
|Odds Ratio||1.22 [1.05-1.40]|
|Trait||Body mass index|
|Title||Six new loci associated with body mass index highlight a neuronal influence on body weight regulation|
|Odds Ratio||0.20 [0.12-0.28] kg/m2 increase|
[PMID 20061430] Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population
[PMID 19812171] Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
[PMID 20181787] A Variant in the Fat Mass and Obesity-Associated Gene (FTO) and Variants near the Melanocortin-4 Receptor Gene (MC4R) Do Not Influence Dietary Intake
[PMID 20215774] Association between a Common Variant near MC4R and Change in Body Mass Index Develops by Two Weeks of Age
[PMID 20406574] Melanocortin-4 receptor gene variants in Chilean families: association with childhood obesity and eating behavior
[PMID 20070976] Common variants near melanocortin 4 receptor are associated with general and visceral adiposity in European- and African-American youth
[PMID 20966902] Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women
[PMID 21085626] Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus
[PMID 20843981] Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children
[PMID 21773004] An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans
[PMID 21303735] Association study of MC4R with complex obesity and replication of the rs17782313 association signal
[PMID 21527513] Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity
|Title||Hundreds of variants clustered in genomic loci and biological pathways affect human height.|
|Odds Ratio||0.0300 [NR] meters decrease|
[PMID 22421923] Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians
[PMID 22563304] The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach
[PMID 22083549] Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
[PMID 18682847] Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes.
[PMID 19016587] How does body fat influence bone mass in childhood? A Mendelian randomization approach.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19073769] Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.
[PMID 19197348] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
[PMID 19255736] Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.
[PMID 19470880] Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype.
[PMID 19526209] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
[PMID 19553259] Common body mass index-associated variants confer risk of extreme obesity.
[PMID 19557197] NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
[PMID 19629057] Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss.
[PMID 19668254] Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study.
[PMID 19750184] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
[PMID 19844209] Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.
[PMID 19880856] Life course variations in the associations between FTO and MC4R gene variants and body size.
[PMID 20017980] A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data.
[PMID 20092643] Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).
[PMID 20127379] From monogenic to polygenic obesity: recent advances.
[PMID 20161779] Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
[PMID 20520848] Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.
[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 20725061] MC4R variant is associated with BMI but not response to resistance training in young females.
[PMID 20824172] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
[PMID 21063808] Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations.
[PMID 21147891] Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study.
[PMID 21210875] Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults.
[PMID 21283731] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
[PMID 21347432] The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women.
[PMID 21372613] Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention.
[PMID 21593506] Maternal and offspring adiposity-related genetic variants and gestational weight gain.
[PMID 21688152] Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk.
[PMID 22310352] Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene.
[PMID 22350153] A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population.
[PMID 22466342] beta2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.
[PMID 22511254] Susceptibility variants for obesity and colorectal cancer risk: The multiethnic cohort and PAGE studies.
[PMID 22614171] Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.
[PMID 23049848] Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis
[PMID 23054017] The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23130628] Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low
[PMID 23277235] Association of the Common MC4R rs17782313 Polymorphism With Antipsychotic-Related Weight Gain
[PMID 23431394] Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in chinese han population independently of body mass index
[PMID 23447422] A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents
[PMID 23424664] Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children
[PMID 23151679] Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
[PMID 24269186] An obesity genetic risk score is associated with metabolic syndrome in Chinese children
[PMID 24385306] The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity
[PMID 24458996] Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults
[PMID 22869321] Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals.
[PMID 23147118] Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review.
[PMID 23201545] FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention.
[PMID 23318717] Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.
[PMID 23460509] Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population.
[PMID 23588626] Associations of obesity susceptibility loci with hypertension in Chinese children.
[PMID 23775818] Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study.
[PMID 23849767] Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension.
[PMID 24762112] Increased body mass index, elevated C-reactive protein, and short telomere length
[PMID 24880622] A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study
[PMID 25492288] [Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood]
[PMID 25769385] The association of MC4R rs17782313 polymorphism with dietary intake in Iranian adults
[PMID 25948074] Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort
[PMID 25966591] [Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population]
[PMID 26588347] Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults
[PMID 27377581] Association of the FTO (rs9939609) and MC4R (rs17782313) gene polymorphisms with maternal body weight during pregnancy.
|Disease||antipsychotics response - Toxicity/ADR|
|CLNDBN||antipsychotics response - Toxicity/ADR|
|CLNSRC||PharmGKB Clinical Annotation PharmGKB|
[PMID 27829468] Fat mass obesity-associated (FTO) (rs9939609) and melanocortin 4 receptor (MC4R) (rs17782313) SNP are positively associated with obesity and blood pressure in Mexican school-aged children.