rs6265(A;G)

Slightly increased risk for ADHD or depression; somewhat quicker mental decline in Alzheimer patients

Is a	genotype
of	rs6265
Gene	BDNF, BDNF-AS
Chromosome	11
Position	27,658,369
mentioned	by

Magnitude

2.6

Repute

Bad

Geno	Mag	Summary
(A;A)	2.6	introversion; depression resistant; impaired motor skills learning; somewhat quicker mental decline in Alzheimer patients
(A;G)	2.6	Slightly increased risk for ADHD or depression; somewhat quicker mental decline in Alzheimer patients
(G;G)	0	common/normal

Some studies indicate that this genotype is associated with slightly increased risk for certain mental health disorders; other studies have found no association. [PMID 20682308] [PMID 20087404 ][PMID 20033742] [PMID 19699537] [PMID 18286632] [PMID 15940292] [PMID 20943059] [PMID 19603419] [PMID 18600033]

Also, On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. [PMID 19745020]

wiredscience/2009/10/ genetically-bad-driving/ Wired discusses the research as does 10/30/snpwatch-the-bad- driving-gene/ 23andMe blog.

[PMID 17293537] Alzheimer's disease risk for non ApoE4 carriers is affected by the heterozygous form of rs6265