|17x myopathy risk for statin users|
||17x myopathy risk for statin users
||reduced breakdown of some drugs; 5x increased myopathy risk for statin users
reduced breakdown of some drugs;
CPIC Recommendation: Prescribe a lower dose (20mg daily) or consider an alternative statin (e.g., pravastatin or rosuvastatin); consider routine creatine kinase (CK) surveillance.
significantly associated with myopathy in patients who received simvastatin, but not in patients who received atorvastatin. [PMID 21243006]
[PMID 21851379] however it did not affect pravastatin.