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Atorvastatin

From SNPedia

Atorvastatin is the chemical name for the statin drug marked under the brand names Lipitor.

Atorvastatin therapy is an example of a statin therapy that has been shown to substantially reduce the risk of coronary events in carriers of the risk allele for SNP rs20455.[PMID 18222353]

PGx Table for Atorvastatin (Lipitor)
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
rs7412(C;C) non ApoE2 carrier APOE Statin Cardiology Consider Alternatives You may have less of a response to atorvastatin (less reduction in LDL-cholesterol) compared to other genotypes for this variant.
rs7412(C;T) E2 carrier (likely) APOE Statin Cardiology Normal Response Expected You may have a better response to atorvastatin (greater reduction in LDL-cholesterol) compared to non-ApoE2 carriers.
rs7412(T;T) E2/E2 (likely) APOE Statin Cardiology Normal Response Expected You may have a better response to atorvastatin (greater reduction in LDL-cholesterol) compared to non-ApoE2 carriers.