|(C;C)||0||common in complete genomics|
each C at rs2237892 increased the odds of type 2 diabetes by 1.4 times, compared to the TT genotype. Itâ€™s important to note, however, that the C version is actually pretty common.
In Asian populations, the C version of rs2237892 increased a personâ€™s odds of type 2 diabetes by 1.42 times compared to people with TT. But because about 50% of the Asian population is actually CT at this SNP, it could be viewed that CC has 1.3 times the odds compared to typical, while TT has 0.61 times the typical odds.
In European populations, about 85% of people are CC. This means that the results of Yasuda et al really show that compared to most Europeans, people with CT at rs2237892 have 0.78 times the typical odds of developing type 2 diabetes, and the odds for people with TT are 0.52 times typical.
[PMID 19366866] Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
|Trait||Type 2 diabetes|
|Title||Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus|
|Odds Ratio||1.40 [1.34-1.47]|
|Trait||Type 2 diabetes|
|Title||Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population|
|Odds Ratio||1.33 [1.27-1.41]|
[PMID 19448982] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China
[PMID 19516902] The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
[PMID 19308350] Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
[PMID 19575309] Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population
[PMID 19850681] Association of KCNQ1 Polymorphisms with the Gestational Diabetes Mellitus in Korean Women
[PMID 20512086] Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: A case-control study and meta-analysis
|Title||Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.|
|Odds Ratio||1.2000 [1.11-1.29]|
[PMID 22403629] Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp
[PMID 22479571] Several Polymorphisms of KCNQ1 Gene Are Associated with Plasma Lipid Levels in General Chinese Populations
[PMID 22206064] KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects
[PMID 22693455] Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
[PMID 18991055] Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
[PMID 19033397] Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.
[PMID 19252135] Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.
[PMID 19323962] Genome-wide association studies in type 2 diabetes.
[PMID 19460916] Genetic architecture of type 2 diabetes: recent progress and clinical implications.
[PMID 19526209] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
[PMID 19556355] Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
[PMID 19750184] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
[PMID 19862325] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 20509872] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
[PMID 20606385] Polymorphisms in KCNQ1 are associated with gestational diabetes in a Korean population.
[PMID 20701788] KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.
[PMID 21261977] Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 21289621] Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.
[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
[PMID 22377714] Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea.
[PMID 22414228] KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese Type 2 diabetic patients.
[PMID 22461567] Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23133642] The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis
[PMID 23271129] Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes
[PMID 23029294] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus
|Trait||Type 2 diabetes|
|Title||A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.|
|Odds Ratio||1.32 [1.19-1.46]|
[PMID 23786590] Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis
[PMID 22790062] Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes.
[PMID 22923468] Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
[PMID 23107108] Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs.
[PMID 23630301] Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.
[PMID 23692438] Association between KCNQ1 genetic variants and QT interval in a Chinese population.
|Trait||Type 2 diabetes|
|Title||Genome-wide association study identifies three novel loci for type 2 diabetes.|
|Odds Ratio||1.30 [1.24-1.36]|
|Trait||Body mass index|
|Title||Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.|
|Odds Ratio||.03 [0.022-0.038] unit increase|
[PMID 26678516] Variant rs2237892 of KCNQ1 Is Potentially Associated with Hypertension and Macrovascular Complications in Type 2 Diabetes Mellitus in A Chinese Han Population.
[PMID 28863213] Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population.