rs1800566(C;T)
From SNPedia
Possible Lower Lung Cancer risk |
Is a | genotype |
of | rs1800566 |
Gene | NQO1 |
Chromosome | 16 |
Position | 69,711,242 |
mentioned | by |
Magnitude | 1.8 |
Repute | Good |
Geno | Mag | Summary |
---|---|---|
(C;C) | 0 | common in clinvar |
(C;T) | 1.8 | Possible Lower Lung Cancer risk |
(T;T) | 3.1 | Benzene toxicity; cancer risks |
rs1800566 may decrease susceptibility to Lung Cancer 0.48 times for heterozygotes (CT) due to the presence of the T allele reducing the rate at which the pro-carcinogenic activating NOD1 enzyme operates [PMID 15498787]