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From SNPedia

Known as C609T and P187S; Encodes NAD(P)H dehydrogenase (quinone 1)
Geno Mag Summary
(C;C) 0 common in clinvar
(C;T) 1.8 Possible Lower Lung Cancer risk
(T;T) 3.1 Benzene toxicity; cancer risks
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs1800566
1000 genomesrs1800566
GWAS Ctlgrs1800566
Max Magnitude3.1
? (C;C) (C;T) (T;T) 28

rs1800566 (C609T, Pro187Ser) is a snp within NQO1 (NAD(P)H dehydrogenase (quinone 1)). A Ser (T) at this location denotes the NQO1*2 allele.

PubMed [PMID 15498787]
Affy Probeset SNP_A-2252005
Affy Orientation same
On GW 5.0 1
Alleles A/B C/T
Ancestral C
Allele T
Case Freq.
Control Freq.
Odds Ratio Het 0.48
Odds Ratio Hom
Odds Ratio All
Disease Lung cancer (LC)

influences the risk of breast cancer according to the 23andMe blog

rs1800566(C;T) heterozygotes have 0.48x reduced risk for Lung cancer [PMID 15498787]


[PMID 19778569] Oxidative stress in tardive dyskinesia: Genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes

[PMID 20331656] Fetal Genotype for the Xenobiotic Metabolizing Enzyme NQO1 Influences Intrauterine Growth Among Infants Whose Mothers Smoked During Pregnancy

[PMID 20110814OA-icon.png] Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution

[PMID 20391128] Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population

[PMID 20663217OA-icon.png] Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China

[PMID 21133623] No Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T Polymorphism and Risk of Hepatocellular Carcinoma Development in Turkish Subjects


[PMID 22215148] Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis

[PMID 22272361OA-icon.png] A Functional NQO1 609C>T Polymorphism and Risk of Gastrointestinal Cancers: A Meta-Analysis

[PMID 21351093] Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas

[PMID 22573488] EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients

[PMID 22016051] Leads from xenobiotic metabolism genes for Parkinson's disease among north Indians

Risk Rs1800566(T;T)
Alt Rs1800566(T;T)
Reference Rs1800566(C;C)
Significance Other
Disease Benzene toxicity Leukemia Breast cancer Alkylating Agents Lung cancer
Variation info
Gene NQO1
CLNDBN Benzene toxicity, susceptibility to Leukemia, post-chemotherapy, susceptibility to Breast cancer, post-chemotherapy poor survival in Alkylating Agents, anthracyclines and related substances, fluorouracil, and Platinum compounds response - Efficacy Lung cancer
Reversed 1
HGVS NC_000016.9:g.69745145G>A
CLNSRC OMIM Allelic Variant PharmGKB Clinical Annotation UniProtKB (protein)
CLNACC RCV000018300.2, RCV000018301.2, RCV000018302.23, RCV000211294.1, RCV000434090.1,

[PMID 15576619OA-icon.png] Hematotoxicity in workers exposed to low levels of benzene.

[PMID 16026601OA-icon.png] Decision forest analysis of 61 single nucleotide polymorphisms in a case-control study of esophageal cancer; a novel method.

[PMID 16385446OA-icon.png] A testing framework for identifying susceptibility genes in the presence of epistasis.

[PMID 17160896OA-icon.png] Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.

[PMID 17366837OA-icon.png] Genetic studies of a cluster of acute lymphoblastic leukemia cases in Churchill County, Nevada.

[PMID 17424838] [Genetic polymorphisms of MPO, NQO1, GSTP1, UGT1A6 associated with susceptibility of chronic benzene poisoning].

[PMID 17697348OA-icon.png] Technology to accelerate pangenomic scanning for unknown point mutations in exonic sequences: cycling temperature capillary electrophoresis (CTCE).

[PMID 17885617] Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations.

[PMID 18191955OA-icon.png] Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.

[PMID 18214807] Association of the NQO1, MPO, and XRCC1 polymorphisms and chromosome damage among workers at a petroleum refinery.

[PMID 18535201OA-icon.png] A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.

[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 18632753OA-icon.png] Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.

[PMID 18854777OA-icon.png] Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.

[PMID 18922824OA-icon.png] Genetic susceptibility to childhood leukaemia.

[PMID 18936436OA-icon.png] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

[PMID 18992148OA-icon.png] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

[PMID 19174490OA-icon.png] Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

[PMID 19494791] NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.

[PMID 19822020OA-icon.png] Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

[PMID 20049130OA-icon.png] Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study.

[PMID 20049212OA-icon.png] Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS).

[PMID 20091863] Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.

[PMID 20966810] Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.

[PMID 21034357OA-icon.png] DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.

[PMID 21706157] NQO1 expression correlates inversely with NFkappaB activation in human breast cancer.

[PMID 21946896] Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy.

[PMID 22200898] Maternal smoking during pregnancy, genetic polymorphisms of metabolic enzymes, and childhood acute leukemia: the ESCALE study (SFCE).

[PMID 22976839] NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution

[PMID 23276910] Association between polymorphism of the NQO1, NOS3 and NFE2L2 genes and AMD

[PMID 23534750] Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) Genes in Thai Cervical Cancer Patients with HPV 16 Infection

[PMID 23651475OA-icon.png] Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study

[PMID 24354914] NQO1 rs1800566 C>T polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population

[PMID 24571676OA-icon.png] RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

[PMID 22972504] A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population.

[PMID 22987024] Aromatic DNA adducts and number of lung cancer risk alleles in Map-Ta-Phut Industrial Estate workers and nearby residents.

[PMID 23054000] Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.

[PMID 23175176OA-icon.png] Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.

[PMID 24755231OA-icon.png] NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis

[PMID 24830960] Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer

[PMID 25054016OA-icon.png] Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies

[PMID 26451011OA-icon.png] Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas

[PMID 27078674] Genetic association of NAD(P)H Quinone Oxidoreductase (NQO1*2) polymorphism with NQO1 levels and risk of diabetic nephropathy

[PMID 27279837OA-icon.png] Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population.

[PMID 32185238OA-icon.png] Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia.