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rs17612858(T;T)

From SNPedia

highest risk (~5x higher) for podoconiosis
Is agenotype
ofrs17612858
GeneHLA-DQA1
Chromosome6
Position32,652,845
mentionedby
Magnitude3
ReputeBad
Geno Mag Summary
(A;A) 0 lowest risk of Podoconiosis
(A;T) 2 higher risk (~2x) for podoconiosis
(T;T) 3 highest risk (~5x higher) for podoconiosis

The presence of the minor allele (T) of this SNP was associated with an increased risk of susceptibility to podoconiosis substantially (odds ratio, 2.44 in the allelic model and 2.19 in the additive model). This is a neglected tropical disease which causes elephantiasis when exposed to volcanic soil. [PMID 22455414]

An estimated one-fifth of Ethiopians carry this genotype, increasing their risk for this debilitating disease. http://www.genome.gov/27558535