Have questions? Visit https://www.reddit.com/r/SNPedia

rs17612858

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 lowest risk of Podoconiosis
(A;T) 2 higher risk (~2x) for podoconiosis
(T;T) 3 highest risk (~5x higher) for podoconiosis
ReferenceGRCh38 38.1/141
Chromosome6
Position32652845
GeneHLA-DQA1
is asnp
is mentioned by
dbSNPrs17612858
dbSNP (old)rs17612858
ClinGenrs17612858
ebirs17612858
HLIrs17612858
Exacrs17612858
Gnomadrs17612858
Varsomers17612858
Maprs17612858
PheGenIrs17612858
Biobankrs17612858
1000 genomesrs17612858
hgdprs17612858
ensemblrs17612858
gopubmedrs17612858
geneviewrs17612858
scholarrs17612858
googlers17612858
pharmgkbrs17612858
gwascentralrs17612858
openSNPrs17612858
23andMers17612858
23andMe allrs17612858
SNP Nexus

SNPshotrs17612858
SNPdbers17612858
MSV3drs17612858
GWAS Ctlgrs17612858
GMAF0.4674
Max Magnitude3

rs17612858 represents a variant near the HLA-DQA1 gene, located on chromosome 6.

A relatively small genomewide association study (~200 patients followed by validation) of southern Ethiopians concluded that the rs17612858(T) allele significantly increases risk for podoconiosis, a tropical lymphedema resulting from long-term barefoot exposure to red-clay volcanic soil. Compared to the major (A;A) homozygote, the odds ratio was 1.7 (CI: 1 - 2.7) for (A;T) heterozygotes and 4.6 (CI: 2.6 - 8) for (T;T) minor allele homozygotes.[PMID 22455414OA-icon.png]