Rs9465871
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs9465871 |
| hapmap | rs9465871 |
| hgdp | rs9465871 |
| ensembl | rs9465871 |
| gopubmed | rs9465871 |
| scholar | rs9465871 |
| rs9465871 | |
| pharmgkb | rs9465871 |
| hgvbaseg2p | rs9465871 |
| medrefsnp | rs9465871 |
| 23andMe | rs9465871 |
| SNP Nexus |
| Gene | CDKAL1 |
| Chromosome | 6 |
| Orientation | plus |
| Position | 20825233 |
| Genotype | Effect |
|---|---|
| rs9465871(C;C) | 2.2x risk type-2 diabetes |
| rs9465871(C;T) | 1.2x risk type-2 diabetes |
| rs9465871(T;T) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs9465871(C;C) | 2.2x risk type-2 diabetes | |
| Rs9465871(C;T) | 1.2x risk type-2 diabetes | |
| Rs9465871(T;T) | 00 | normal |
The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.18 (CI 1.04-1.34), and for homozygotes, 2.17 (CI 1.6-2.95). [PMID 17554300]
[PMID 18633108] When combined, each additional risk allele from rs9465871, rs10811661, rs4402960, and rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)) in Chinese Hans
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs9465871 |
| PubMedID | [PMID 17554300] |
| Condition | Type 2 diabetes |
| Gene | CDKAL1 |
| Risk Allele | C |
| pValue | 3.00E-007 |
| OR | 1.18 |
| 95% CI | 1.04-1.34 |
Related to DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
according to omim 125853. See also
| PharmGKB | PA162356659 |
| Name | |
| Annotation | GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: (see Zeggini 2007); Risk Allele: rs9465871-C). This variant is associated with type 2 diabetes. |
| Gene | CDKAL1 |
| Featue | |
| Evidence | PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Diabetes Mellitus, Diabetes Mellitus, Type 2 |
| Curation Level | Non-Curated |
