Rs4402960
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs4402960 |
| hapmap | rs4402960 |
| hgdp | rs4402960 |
| ensembl | rs4402960 |
| gopubmed | rs4402960 |
| scholar | rs4402960 |
| rs4402960 | |
| pharmgkb | rs4402960 |
| hgvbaseg2p | rs4402960 |
| medrefsnp | rs4402960 |
| 23andMe | rs4402960 |
| SNP Nexus |
| Gene | IGF2BP2 |
| Chromosome | 3 |
| Orientation | plus |
| Position | 186994380 |
| Genotype | Effect |
|---|---|
| rs4402960(G;G) | normal |
| rs4402960(G;T) | 1.2x increased risk for type-2 diabetes |
| rs4402960(T;T) | 1.2x increased risk for type-2 diabetes |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs4402960(G;G) | 00 | normal |
| Rs4402960(G;T) | 1.2x increased risk for type-2 diabetes | |
| Rs4402960(T;T) | 1.2x increased risk for type-2 diabetes |
[PMID 18477659] rs4402960 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.23 (CI: 1.11-1.36, p = 8.1 x 10e-5)
[PMID 17463248] associated with type-2 diabetes
[PMID 18162508] significantly associated with type-2 diabetes p = 0.00009; in 1,630 Japanese subjects and in 1,064 controls
[PMID 18437351] 1,638 type-2 diabetes patients and 1,858 controls
- rs4402960 borderline (OR 1.10, 95% CI: 0.99-1.22).
[PMID 18430866] Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians.
[PMID 19033397] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).
Note: rs4402960 is fairly tightly linked (r2=0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs1470579
Called into question by table 1 of 10.1371/journal.pbio.1000294
| ? | (G;G) (G;T) (T;T) |
|---|---|
|
| |
| GWAS | |
|---|---|
| SNP | rs4402960 |
| PubMedID | [PMID 17463249] |
| Condition | Type 2 diabetes |
| Gene | IGF2BP2 |
| Risk Allele | T |
| pValue | 9.00E-016 |
| OR | 1.14 |
| 95% CI | 1.11-1.18 |
[PMID 19258437] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.
| GWAS snp | |
|---|---|
| PMID | [PMID 18372903] |
| Trait | Type 2 diabetes |
| Title | Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes |
| Risk Allele | T |
| P-val | 8.0000000000000002E-8 |
| Odds Ratio | 1.17 [1.10-1.25] |
| GWAS snp | |
|---|---|
| PMID | [PMID 17463246] |
| Trait | Type 2 diabetes |
| Title | Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels |
| Risk Allele | T |
| P-val | 9.0000000000000003E-16 |
| Odds Ratio | 1.14 [1.11-1.18] |
| GWAS snp | |
|---|---|
| PMID | [PMID 19401414] |
| Trait | Type 2 diabetes |
| Title | Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population |
| Risk Allele | T |
| P-val | 0.000001 |
| Odds Ratio | 1.14 [1.08-1.21] |
| PharmGKB | PA162168095 |
| Name | |
| Annotation | rs4402960 demonstrated association with Type 2 Diabetes in a GWAS of Finnish and Swedish patients and controls. |
| Gene | IGF2BP2 |
| Featue | |
| Evidence | PubMed ID:17463246 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 2 |
| Curation Level | Curated |
[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
[PMID 20215779] Evidence of Interaction between Type 2 Diabetes Susceptibility Genes and Dietary Fat Intake for Adiposity and Glucose Homeostasis-Related Phenotypes
