Rs13266634

From SNPedia

rs13266634 is a SNP in the zinc transporter protein member 8 SLC30A8 gene that has primarily been associated with type-2 diabetes in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W).

[PMID 18162508] significantly associated p = 0.0073; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls

The major alleles of the SLC30A8 SNP rs13266634 and the HHEX SNP rs7923837 associate with reduced insulin secretion, but not with insulin resistance. [PMID 17786204]

[PMID 18324385] 46% of European non-diabetic offspring of type-2 diabetes patients are rs13266634(C;C) homozygotes; they are diabetes-prone and characterised by a 19% decrease in first-phase insulin release following an intravenous glucose load.

• Note: this SNP, rs13266634, is not represented on the Affymetrix 5.0 chip. Since it is also in an area of high recombination, it also lacks a proxy on the Affy chip and thus could not have been detected in the large genome-wide type-2 diabetes study performed by the Wellcome Trust Consortium. [PMID 17554300]

[PMID 18437351] 1,638 type-2 diabetes patients and 1,858 controls

• rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p = 3.9 x 10(-4)).

[PMID 18548167] rs13266634(C) allele is associated with younger age of onset of type-1 diabetes

[PMID 19033397] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

spitotoon associated with blood sugar levels (glycated hemoglobin levels) rs13266634(C)

GWAS
SNP	rs13266634
PubMedID	[PMID 17293876]
Condition	Type 2 diabetes
Gene	SLC30A8
Risk Allele	C
pValue	6.00E-008
OR	1.18
95% CI	0.69-1.67

[PMID 19258437] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.

[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

GWAS snp
PMID	[PMID 19056611]
Trait	Type 2 diabetes
Title	Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
Risk Allele
P-val	0.000007
Odds Ratio	1.18 [1.10-1.27]

GWAS snp
PMID	[PMID 17463246]
Trait	Type 2 diabetes
Title	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Risk Allele	C
P-val	4.9999999999999998E-8
Odds Ratio	1.12 [1.07-1.16]

GWAS snp
PMID	[PMID 17463248]
Trait	Type 2 diabetes
Title	A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Risk Allele	C
P-val	4.9999999999999998E-8
Odds Ratio	1.12 [1.07-1.16]

GWAS snp
PMID	[PMID 17460697]
Trait	Type 2 diabetes
Title	A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Risk Allele	C
P-val	0.0000030000000000000001
Odds Ratio	1.15 [1.08-1.22]

GWAS snp
PMID	[PMID 17463249]
Trait	Type 2 diabetes
Title	Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
Risk Allele	C
P-val	5E-8
Odds Ratio	1.12 [1.07-1.16]

GWAS snp
PMID	[PMID 19401414]
Trait	Type 2 diabetes
Title	Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
Risk Allele	C
P-val	2E-14
Odds Ratio	1.22 [1.16-1.28]

[PMID 19590848] Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk

[PMID 19655390] Zn(2+)-transporter-8: A dual role in diabetes

[PMID 19741166] Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)

GWAS snp
PMID	[PMID 19734900]
Trait	Type 2 diabetes and other traits
Title	Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Risk Allele	C
P-val	8E-8
Odds Ratio	1.16 [1.10-1.22]

[PMID 20167458] SLC30A8 polymorphism and type 2 diabetes risk: Evidence from 27 study groups