Rs10811661

From SNPedia

[PMID 18477659] rs10811661 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.15-1.40, p = 1.9 x 10e-6)

rs10811661 is mentioned in part 2 of a series

[PMID 18162508] significantly associated with type-2 diabetes p = 0.0024; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls

[PMID 18437351] 1,638 type 2 diabetes patients and 1,858 controls

• rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p = 0.004)

[PMID 18461161] T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for

• CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9))
• CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8))
• IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs.

T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24)

[PMID 18368387] Association between [r[s10811661]] and type-2 diabetes was replicated in a French Europid population, with an odds ratio of 1.43 (CI: 1.24-1.64, p = 3.8 x 10e-7).

[PMID 19033397] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

GWAS
SNP	rs10811661
PubMedID	[PMID 17463249]
Condition	Type 2 diabetes
Gene	CDKN2A/B
Risk Allele	T
pValue	8.00E-015
OR	1.2
95% CI	1.14-1.25

[PMID 19258437] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.

GWAS snp
PMID	[PMID 19056611]
Trait	Type 2 diabetes
Title	Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
Risk Allele
P-val	7E-7
Odds Ratio	1.26 [1.15-1.38]

GWAS snp
PMID	[PMID 17463246]
Trait	Type 2 diabetes
Title	Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Risk Allele	T
P-val	8.0000000000000006E-15
Odds Ratio	1.20 [1.14-1.25]

GWAS snp
PMID	[PMID 17463248]
Trait	Type 2 diabetes
Title	A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Risk Allele	T
P-val	8.0000000000000006E-15
Odds Ratio	1.20 [1.14-1.25]

[PMID 19463184] Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease

[PMID 20018066] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study

[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study