From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
1.2x higher risk for spondylitis
|
| (A;G)
|
|
1.2x higher risk for spondylitis
|
| (G;G)
|
|
normal risk
|
| (T;T)
|
0
|
|
| ? | (A;A) (A;G) (G;G) | 28 |
|---|
 |
is one of several SNPs in the
IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with
ankylosing spondylitis. The odds ratio is 1.2 (p=6.6x10e-6).[
PMID 17952073,
PMID 18037607]
23andMe reports that the CC genotype at rs1495965 is associated with 1.56x higher odds of Behçet's disease, and the TT genotype with 0.64x lower odds, than the CT genotype. [PMID 20622879]
[PMID 18713787] rs11209032 and rs1495965 no significant association with systemic sclerosis
[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility
[PMID 19334001] Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans
| GWAS snp
|
| PMID
|
[PMID 20622879]
|
| Trait
|
Behcet's disease
|
| Title
|
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci
|
| Risk Allele
|
G
|
| P-val
|
2E-11
|
| Odds Ratio
|
1.35 [1.24-1.47]
|
[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
