Ankylosing spondylitis

From SNPedia

Wikipedia has articles on both spondylitis and ankylosing spondylitis, which is basically an autoimmune arthritis of the spine that tends to have its first onset in young adults. It is considered to be highly heritable, with over 90% of the risk of developing the disease being genetically based.

SNPs in at least 3 genes have been fairly strongly implicated in ankylosing spondylitis [PMID 17952073]:

• HLA-B27, the first and still most prominent association
  • Over 40 allelic variants are known, the most common being B2705

• The ARTS1 gene, accounting for ~26% of the population attributable risk
  • rs27044
  • rs17482078
  • rs10050860
  • rs30187
  • rs2287987

• The IL23R gene, accounting for ~10% of the population attributable risk
  • rs11209026, also involved in Crohn's and IBD
  • rs1004819
  • rs10489629
  • rs11465804
  • rs1343151
  • rs10889677