FKBP5
From SNPedia
| is a | gene |
| is | mentioned by |
| wikipedia | FKBP5 |
| FKBP5 | |
| gopubmed | FKBP5 |
| 23andMe | FKBP5 |
dbSNP 2289
PubMed 2289
SADR 2289
HugeNav 2289
HEFalMp FKBP5
| Chromosome position | Summary | |
|---|---|---|
| Rs1360780 | 3571554835,715,548 | |
| Rs3800373 | 3565045335,650,453 | |
| Rs4713902 | 3572200335,722,003 | |
| Rs7757037 | 3565621335,656,213 | |
| Rs9296158 | 3567505935,675,059 | |
| Rs9470080 | 3575441235,754,412 |
The FKBP5 gene appears to influence glucocorticoid function, mediated by a complex formed with the glucocorticoid receptor.
SNPs in the FKBP5 gene have been associated with several psychiatric disorders:
- Response to antidepressants has been seen for:
- rs4713916, in the promoter region
- rs1360780, in intron 2, which also is correlated with overall depression risk
- rs3800373, in the 3' untranslated region
- An association with bipolar disorder has been reported for:
Post Traumatic Stress Disorder [1]
