From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
normal
|
| (C;T)
|
|
0.69x decreased risk for bipolar disorder
|
| (T;T)
|
0
|
0.47x decreased risk for bipolar disorder
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
, a SNP in the
FKBP5 gene, is associated with increased risk for
bipolar disorder in a study of 500+ Caucasian patients.
The most common allele, rs4713902(T), was associated with highest risk. Giving that allele a relative odds ratio of 1.0, the odds for the (C;T) and (C;C) genotypes were 0.69x (CI:0.55-0.88, p=0.001) and 0.47 (CI: 0.30-0.74, p=0.001).[PMID 18180755]
[PMID 20090668] Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
