Rs7757037
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs7757037 |
| hapmap | rs7757037 |
| hgdp | rs7757037 |
| ensembl | rs7757037 |
| gopubmed | rs7757037 |
| scholar | rs7757037 |
| rs7757037 | |
| pharmgkb | rs7757037 |
| hgvbaseg2p | rs7757037 |
| medrefsnp | rs7757037 |
| 23andMe | rs7757037 |
| SNP Nexus |
| Gene | FKBP5 |
| Chromosome | 6 |
| Orientation | plus |
| Position | 35656213 |
| Genotype | Effect |
|---|---|
| rs7757037(G;G) | normal |
| rs7757037(A;G) | 0.68x decreased risk for bipolar disorder |
| rs7757037(A;A) | 0.63x decreased risk for bipolar disorder |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs7757037(A;A) | 0.63x decreased risk for bipolar disorder | |
| Rs7757037(A;G) | 0.68x decreased risk for bipolar disorder | |
| Rs7757037(G;G) | 00 | normal |
rs7757037, a SNP in the FKBP5 gene, is associated with increased risk for bipolar disorder in a study of 500+ Caucasian patients.
The most common allele, rs7757037(G), was associated with highest risk. Giving that allele a relative odds ratio of 1.0, the odds for the (A;G) and (A;A) genotypes were 0.68x (CI:0.53-0.87, p=0.007) and 0.63x (CI: 0.45-0.89, p=0.007).[PMID 18180755]
| ? | (A;A) (A;G) (G;G) |
|---|---|
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