Promethease 0.1.82

From SNPedia

Bipolar disorder is a psychiatric disorder characterized by recurrent large mood swings; it has also been referred to as manic-depressive illness. An article in Wikipedia provides further general details. The heritability of bipolar disorder is around 70% [PMID 14601036].

SNPs in quite a few genes have been associated with increased risk for bipolar disorder, although most are calculated to be of low effect individually and few are seen to be replicated in diverse populations. Some of the reported SNPs include:

• An increase in GSK3B gene CNVs [PMID 17357145]

• rs3847953 and rs933399

• Three SNPs in the BCR gene: rs140504, rs131690 and rs131702

• Two SNPs in the TPH2 gene: rs11178997 and rs17110563

• Two SNPs in the FKBP5 gene: rs4713901 and rs7757037

• Three SNPS in a multi-locus interaction: rs534654, rs1534891, rs6442925

• One SNP in the DGKH gene: rs1170191

• Several SNPs in the BDNF gene [PMID 19018231]

A quite large 2007 study revealed numerous SNPs, though generally each has relatively low effects on it's own; these include [PMID 17554300]:

• rs420259
• rs4027132
• rs7570682
• rs1375144
• rs2953145
• rs4276227
• rs683395
• rs6458307
• rs2609653
• rs10982256
• rs10134944
• rs11622475
• rs1344484
• rs3761218

Somewhat apart from all these studies, SNPs in the GRK3 gene are said to be implicated in at least some bipolar disorder patients; see the GRK3 gene entry for more information.

[PMID 19488044] reports that SNPs contributing to bipolar disorder may vary based on ancestry, based on differences observed between individuals of European ancestry compared to African ancestry.

genetic future does an introduction to the genetics of bipolar disorder.