From SNPedia
| Geno
|
Mag
|
Summary
|
| (G;G)
|
|
0.68x lower risk for spondylitis
|
| (G;T)
|
|
0.68x lower risk for spondylitis
|
| (T;T)
|
0
|
normal risk
|
| ? | (G;G) (G;T) (T;T) | 28 |
|---|
 |
is one of several SNPs in the
IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with
ankylosing spondylitis. The odds ratio is 0.68 (p=0.0002).[
PMID 17952073,
PMID 18037607]
| GWAS snp
|
| PMID
|
[PMID 18587394]
|
| Trait
|
Crohn's disease
|
| Title
|
Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease
|
| Risk Allele
|
T
|
| P-val
|
7.0000000000000001E-63
|
| Odds Ratio
|
2.50 [NR]
|
| PharmGKB | PA162356492 |
| Name | |
| Annotation | GWAS results: Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci (Initial Sample Size: 382 trios; Replication Sample Size: 521 trios, 750 cases, 828 controls). This variant is associated with Crohn's disease. This variant is associated with Crohn's disease. |
| Gene | IL23R |
| Featue | |
| Evidence | PubMed ID:17804789; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Crohn Disease |
| Curation Level | Non-Curated |
| GWAS snp
|
| PMID
|
[PMID 20570966]
|
| Trait
|
Crohn's disease
|
| Title
|
Fucosyltransferase 2(FUT2) Non-Secretor Status is associated with Crohn's Disease
|
| Risk Allele
|
|
| P-val
|
0.000001
|
| Odds Ratio
|
1.89 [1.47-2.44]
|
[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
[PMID 22269043] Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population
[PMID 22440928] Perianal Crohn's Disease: Predictive Factors and Genotype-Phenotype Correlations
