rs776746(G;G)
From SNPedia
| CYP3A5*3 homozygote; CYP3A5 non-expressor |
| Is a | genotype |
| of | rs776746 |
| Gene | CYP3A5, ZSCAN25 |
| Chromosome | 7 |
| Position | 99,672,916 |
| mentioned | by |
| Magnitude | 2.5 |
| Repute | Bad |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | reference allele |
| (A;G) | 2 | carrier of 1 nonfunctional CYP3A5 allele; drug metabolism affects |
| (G;G) | 2.5 | CYP3A5*3 homozygote; CYP3A5 non-expressor |
Impacts metabolism of tacrolimus, an immunosuppressive drug used in organ transplantation. This is the most common phenotype in caucasian and many other populations. Only in africans is expressing the gene common.
