|(A;G)||2||carrier of 1 nonfunctional CYP3A5 allele; drug metabolism affects|
|(G;G)||2.5||CYP3A5*3 homozygote; CYP3A5 non-expressor|
CYP3A5*3 has been studied especially in connection with the metabolism of tacrolimus, an immunosuppressive drug used in organ transplantation. The optimal therapeutic dose is in a relatively narrow window, so blood concentration monitoring is recommended. CYP3A5*3 carriers tend to build up higher levels of tacrolimus than CYP3A5*1 carriers, unless their tacrolimus intake is reduced.
Carrying two non-expressing CYP3A5*3 alleles (in other words, the rs776746(G;G) genotype) is very common among Caucasians (over 85% of all), and is still relatively common (perhaps about half of all people) in many other populations other than those that are of African descent.
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[PMID 18784455] The pharmacokinetics and pharmacogenomics of efavirenz and lopinavir/ritonavir in HIV-infected persons requiring hemodialysis.
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[PMID 20354687] Explaining variability in ciclosporin exposure in adult kidney transplant recipients.
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[PMID 20459744] Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study.
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[PMID 21671989] Dosing equation for tacrolimus using genetic variants and clinical factors.
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[PMID 22469198] Identification of Factors Affecting Tacrolimus Level and 5-Year Clinical Outcome in Kidney Transplant Patients.
[PMID 23146479] Effect of CYP3A5, CYP3A4, and ABCB1 Genotypes as Determinants of Tacrolimus Dose and Clinical Outcomes After Heart Transplantation
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[PMID 23501331] Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients.
[PMID 23584898] CYP3A5*3 polymorphism and cancer risk: a meta-analysis and meta-regression.
[PMID 23734777] Lack of strong effect modification by NFE2L2/CYP3A5/ABO of the risk of venous thrombosis associated with oral hormone therapy.
[PMID 23991193] Novel single nucleotide polymorphisms in interleukin 6 affect tacrolimus metabolism in liver transplant patients
[PMID 25712187] Donor IL-18 rs5744247 polymorphism as a new biomarker of tacrolimus elimination in Chinese liver transplant patients during the early post-transplantation period: results from two cohort studies
[PMID 25992585] Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia
[PMID 26177348] Comparison of tacrolimus and cyclosporin A in CYP3A5 expressing Chinese de novo kidney transplant recipients: a 2-year prospective study
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|Disease||sirolimus response - Dosage Cyclosporine response - Dosage tacrolimus response - Dosage tacrolimus response due to donor genotype - Dosage tacrolimus response - Efficacy|
|CLNDBN||sirolimus response - Dosage cyclosporine response - Dosage, Metabolism/PK tacrolimus response - Dosage, Metabolism/PK tacrolimus response due to donor genotype - Dosage, Metabolism/PK tacrolimus response - Efficacy|
|CLNSRC||PharmGKB Clinical Annotation|
|CLNACC||RCV000211230.1, RCV000211240.1, RCV000211322.1, RCV000211356.1, RCV000211409.1,|
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[PMID 32256016] Importance of genetic polymorphisms in liver transplantation outcomes.