[PMID 22085192] Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence. Alcoholic patients with TGT haplotype (corresponding to rs6454674-rs1049353-rs806368 polymorphisms in this order) were less prone to have AD (p = 0.017). TGC haplotype were more likely to develop AD.
[PMID 18606954] Cannabinoid receptor 1 gene association with nicotine dependence. the associations were female specific. Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368(C) was associated with nicotine dependence and FTND score in the 2 samples (P < .001 and P = .009, respectively).