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From SNPedia

Geno Mag Summary
(A;A) 1.1 0.73x reduced risk of Graves' disease
(A;G) 0 normal
(G;G) 1.2 1.2x risk of Rheumatoid Arthritis; various risks of autoimmune diseases
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs7528684
1000 genomesrs7528684
GWAS Ctlgrs7528684
Max Magnitude1.2
? (A;A) (A;G) (G;G) 28

SNP also known as "-169C/T"

[PMID 16176992OA-icon.png]In a 2006 study, rs7528684 has been reported to be associated with rheumatoid arthritis in a Caucasian population, following reports of a similar association in a Japanese population.

[PMID 17179172OA-icon.png] In this 2007 report, "FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians," The risk allele (oriented to the dbSNP entry) is (G) (which they report as C); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for rs7528684 CC (GG) homozygotes, 2.30 (CI 1.64-3.23). But the "Meta-analysis of all studies comparing 9467 individuals showed that the OR for the CC (GG) genotype to develop RA was 1.2 and the p value <0.001." (Abstract)

[PMID 15838509OA-icon.png] In a 2005 report, a summary indicates the following regarding disease and odds ratio (OR)for rs7528684 :

  • for rheumatoid arthritis: OR = 2.15 (CI = 1.58–2.93), from 830 cases and 658 controls;
  • for SLE: OR = 1.49 (CI = 1.16–1.92), from 564 cases;
  • for Graves' disease : OR = 1.79 (CI = 1.34–2.39), from 351 cases;
  • for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07–2.47), from 158 cases.

[PMID 18087673] rs7528684 rs3792876 and rs2268277 failed to showed a statistically significant association with rheumatoid arthritis

[PMID 18556175] rs7528684, rs11264799, rs945635 and rs3761959 were not associated with systemic lupus erythematosus (SLE) in a study of 248 Chinese Han patients.

[PMID 18313765] In a 2008 study of 645 Caucasians from Southern Spain with multiple sclerosis, the rs7528684(G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007).

[PMID 19438904] Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease Found the AA genotype of PTPN22 rs3789604 and AA genotype of FCRL3 rs7528684 to be protective against Graves' by OD 0.73.

Not on PubMed, (but at 10.1111/j.1464-5491.2006.01848), a 2006 article titled "The functional variant –169C/T in the FCRL3 gene does not increase susceptibility to Type 1 diabetes" found no associations between this SNP's various allele combinations and Type 1 Diabetes in a Finnish population (735 cases and 735 non-diabetic healthy controls)

[PMID 21885492] FCRL3 -169C/C Genotype Is Associated with Anti-citrullinated Protein Antibody-positive Rheumatoid Arthritis and with Radiographic Progression

GWAS snp
PMID [PMID 21829393OA-icon.png]
Title Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Risk Allele T
P-val 1E-11
Odds Ratio 1.5200 [NR]

[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16859508OA-icon.png] Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?

[PMID 17389014] Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.

[PMID 18556337OA-icon.png] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

[PMID 18759263OA-icon.png] Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.

[PMID 19050767OA-icon.png] Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations.

[PMID 19180233OA-icon.png] Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

[PMID 19452015OA-icon.png] Polymorphisms of FCRL3 in a Chinese population with Vogt-Koyanagi-Harada (VKH) syndrome.

[PMID 19877046OA-icon.png] The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.

[PMID 22341374] Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.

[PMID 23505439OA-icon.png] A Refined Study of FCRL Genes from a Genome-Wide Association Study for Graves' Disease

[PMID 23512175] Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis

[PMID 24117236] The Fc receptor-like 3 gene polymorphisms and susceptibility to autoimmune diseases: An updated meta-analysis

[PMID 23564408] The FCRL3 -169T>C polymorphism might be associated with some autoantibody presence in patients with SLE in a Polish population.

[PMID 26051414] FCRL3 gene polymorphisms confer risk for sudden sensorineural hearing loss in a Chinese Han Population

[PMID 25566937OA-icon.png] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis