Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Wikipedia The most studied genetic contributions to SLE involve the major histocompatibility complex (MHC) region on chromosome 6, which contains over 100 genes involved in immune system function.
- The HLA-DRB1*0301 allele from the class II region (see rs2187668)
- rs419788 in the intron of the class III SKIV2L gene
SNPs in genes outside the MHC region may also affect the risk of developing lupus:
- IRF5 on chr 7q32.1