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rs61753344

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0 common in clinvar
(G;T) 2 trimethylaminuria, to varying degrees
(T;T) 3 trimethylaminuria & possible related issues
ReferenceGRCh38 38.1/141
Chromosome1
Position171114092
GeneFMO3
is asnp
is mentioned by
dbSNPrs61753344
dbSNP (old)rs61753344
ClinGenrs61753344
ebirs61753344
HLIrs61753344
Exacrs61753344
Gnomadrs61753344
Varsomers61753344
Maprs61753344
PheGenIrs61753344
Biobankrs61753344
1000 genomesrs61753344
hgdprs61753344
ensemblrs61753344
gopubmedrs61753344
geneviewrs61753344
scholarrs61753344
googlers61753344
pharmgkbrs61753344
gwascentralrs61753344
openSNPrs61753344
23andMers61753344
23andMe allrs61753344
SNP Nexus

SNPshotrs61753344
SNPdbers61753344
MSV3drs61753344
GWAS Ctlgrs61753344
GMAF0.0004591
Max Magnitude3
OMIM136132
Desc
Variant0001
Relatedalso
rs61753344 is a SNP in the FMO3 gene. It has been reported in both homozygous and heterozygous forms to potentially be linked to trimethylaminuria; in the homozygous form, it has also been linked to tachycardia and severe hypertension after eating cheese (which contains tyramine) and after using nasal epinephrine.[PMID 987532]
ClinVar
Risk Rs61753344(T;T)
Alt Rs61753344(T;T)
Reference Rs61753344(G;G)
Significance Pathogenic
Disease Trimethylaminuria
Variation info
Gene FMO3
CLNDBN Trimethylaminuria
Reversed 0
HGVS NC_000001.10:g.171083232G>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000017697.30,



[PMID 9536088] Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.