High blood pressure

The Wikipedia article on high blood pressure gives a general introduction. "High blood pressure" is the common term for the medically accurate term hypertension.

Genetic variation associated with high blood pressure can be divided into

• SNPs that can predispose an individual to hypertension under some or all conditions
• SNPs in genes that play in role in how drugs commonly used to treat hypertension, such as ACE Inhibitors, beta blockers, calcium channel blockers, and diuretics, are used by the body
  • A table listing several ACEI and ARB associated variants is available

SNPs that may predispose individuals to high blood pressure include:

• SNPs in the ADD1 gene:
  • rs4961, linked to rs4963

• SNPs in the AGTR1 gene:
  • rs5186

• SNPs in the NEDD4L gene:
  • rs4149601
  • rs2288774
  • rs3865418

• 6 SNPs from a recent (2007) large study [PMID 17554300]:
  • rs2820037
  • rs6997709
  • rs7961152
  • rs11110912
  • rs1937506
  • rs2398162

• SNPs in the PPARG gene:
  • rs4684847

• 4 SNPs from three loci studied in a Japanese population [PMID 18003638]:
  • rs3755351, a SNP in ADD2 gene
  • rs3794260, a SNP in the KIAA0789 gene
  • rs9739493, another SNP in the KIAA0789 gene
  • rs1805762, a SNP in the M6PR gene

• Two SNPs in the STK39 gene:
  • rs3754777
  • rs6749447

• A SNP in the CYP4A11 gene, found in a Japanese population:
  • rs1126742

• A SNP in the CALCA gene, found in a Chinese population:
  • rs3781719

• [PMID 16565233] A -318 C>G single-nucleotide polymorphism in the GNAI2 gene promoter region is associated with high blood pressure in Caucasians from Italy. Note: this SNP does not appear to have a corresponding entry in dbSNP.

• rs1799983 is a SNP in the NOS3 gene that reflects a 2x higher risk of developing hypertension during pregnancy (pre-eclampsia). [PMID 11745998] This is true for carriers of one or two risk alleles.

SNPs possibly affecting beta blocker therapy for hypertension include:

• rs1801253