|(C;T)||1.5||1.3x increased risk for type-2 diabetes|
|(T;T)||2.5||2.5x increased risk for type-2 diabetes|
This SNP is one of 4 relatively common SNPs reported to represent risk for type-2 diabetes in the DESIR prospective study of 3,877 Caucasian participants. Under an additive model, the odds ratio for the minor (risk) allele (T) is 1.15 (CI: 0.95-1.4, p=0.2, ie not significant). But for the 4 SNPs, each risk allele increased type-2 diabetes risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).[PMID 17977958]
Genotyping of ~4000 Chinese as well a meta-analysis concluded that rs5219 was associated with type-2 diabetes in Chinese Han and East Asian populations, under a recessive model showing an odds ratio of 1.25 (CI: 1.04-1.5, p=0.017).[PMID 19498446]
[PMID 19258437] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.
|Trait||Type 2 diabetes|
|Title||Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data|
|Odds Ratio||1.19 [1.11-1.27]|
|Trait||Type 2 diabetes|
|Title||Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels|
|Odds Ratio||1.14 [1.10-1.19]|
|Trait||Type 2 diabetes|
|Title||A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants|
|Odds Ratio||1.14 [1.10-1.19]|
[PMID 18972257] Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study[PMID 20361036] Gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population
|Disease||Diabetes mellitus type 2 Exercise stress response Permanent neonatal diabetes mellitus not specified Transient Neonatal Diabetes Hyperinsulinism Maturity-onset diabetes of the young|
|CLNDBN||Diabetes mellitus type 2 Exercise stress response, impaired, association with Permanent neonatal diabetes mellitus not specified Transient Neonatal Diabetes, Dominant Hyperinsulinism, Dominant/Recessive Maturity-onset diabetes of the young|
|CLNSRC||OMIM Allelic Variant|
|CLNACC||RCV000009214.4, RCV000009215.4, RCV000020356.2, RCV000146116.3, RCV000281825.1, RCV000294608.1, RCV000385348.1,|
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