Very slightly increased risk for the development of MGUS (Monoclonal Gammopathy of Uncertain Significance). 95% CI .78-1.51. Plausible as the homozygote is more statistically significant and higher risk in the same study. Thus, the major, protective A allele can probably be thought of as acting in a dominant fashion in reducing risk of the development of MGUS. This genotype may be benign - any additional risk conferred is likely minimal.