This is a triallelic SNP - note that the sidebar (currently) only shows 3 of the 6 possible genotypes.
[PMID 18829218] claims that this SNP does not affect the serum concentration of CRP, while older resources seem to disagree. However, they do report an association between CRP levels and risk of abdominal aortic aneurysm (AAA).
|Title||Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study|
|Odds Ratio||0.20 [NR] mg/dl increase|
According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.[PMID 19101671] Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity
[PMID 21413847] Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey
[PMID 21575917] C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants
[PMID 21831326] CRP gene variation affects early development of Alzheimer's disease-related plaques
[PMID 15897982] Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.
[PMID 16534007] Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.
[PMID 16550411] Allelic spectrum of the natural variation in CRP.
[PMID 16723442] A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.
[PMID 16832152] Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.
[PMID 17161935] Genotyping of triallelic SNPs using TaqMan PCR.
[PMID 17900590] C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.
[PMID 17903293] Genome-wide association with select biomarker traits in the Framingham Heart Study.
[PMID 18162041] Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.
[PMID 18167554] C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.
[PMID 18216863] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.
[PMID 18285551] Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.
[PMID 18394581] Bayesian meta-analysis of genetic association studies with different sets of markers.
[PMID 18704199] Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.
[PMID 18714384] The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.
[PMID 18793001] Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 19076828] Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.
[PMID 19095725] Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.
[PMID 19262552] C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.
[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.
[PMID 19336475] Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
[PMID 19410251] Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.
[PMID 19426506] C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.
[PMID 19436291] C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.
[PMID 19545442] Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.
[PMID 19567438] Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
[PMID 19946607] Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.
[PMID 20031577] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
[PMID 20494378] Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.
[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.
[PMID 20714329] C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.
[PMID 21034294] C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.
[PMID 21496483] Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.
[PMID 21647738] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
[PMID 21773944] Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.
[PMID 21979869] C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 22875596] Association study of CRP gene and ischemic stroke in a Chinese Han population
[PMID 23940726] Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an american Indian population
[PMID 24135623] C-reactive protein polymorphism rs3091244 is associated with abdominal aortic aneurysm
[PMID 24762112] Increased body mass index, elevated C-reactive protein, and short telomere length
[PMID 25025473] Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk