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From SNPedia

Make rs3091244(A;A)
Make rs3091244(A;C)
Make rs3091244(A;T)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs3091244
1000 genomesrs3091244
GWAS Ctlgrs3091244
Max Magnitude0

This is a triallelic SNP - note that the sidebar (currently) only shows 3 of the 6 possible genotypes.


[PMID 18829218] claims that this SNP does not affect the serum concentration of CRP, while older resources seem to disagree. However, they do report an association between CRP levels and risk of abdominal aortic aneurysm (AAA).

[PMID 16731635] rs3091244 serum CRP level and cardiovascular risk in the NHLBI Family Heart Study.

[PMID 17101857] the AA genotype of the triallelic SNP rs3091244 in the gene C-reactive protein was associated with prevalent coronary heart disease in the non-Hispanic white population

[PMID 16731635] Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. rs3093059 rs3091244

[PMID 18500540OA-icon.png] Weaker linkage disequilibrium in this region in African Americans allows the conclusion that basal CRP levels are influenced in an additive manner by the T allele.

Non CRP[edit]

[PMID 18055473] increased risk for the presence of severe hand osteoarthritis with an OR of 2.3 (95% confidence interval (C.I.) 1.2-4.3, P = 0.009)

[PMID 18182444] rs3093061 associated with SLE and functional haplotypes containing rs3091244/rs3093062

GWAS snp
PMID [PMID 18439548OA-icon.png]
Trait C-reactive protein
Title Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
Risk Allele
P-val 6.0000000000000001E-28
Odds Ratio 0.20 [NR] mg/dl increase

According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.


[PMID 19101671] Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity


[PMID 21413847] Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey

[PMID 21575917] C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants

[PMID 21831326OA-icon.png] CRP gene variation affects early development of Alzheimer's disease-related plaques

[PMID 15897982OA-icon.png] Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

[PMID 16534007] Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.

[PMID 16550411OA-icon.png] Allelic spectrum of the natural variation in CRP.

[PMID 16723442OA-icon.png] A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

[PMID 16832152] Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

[PMID 17161935] Genotyping of triallelic SNPs using TaqMan PCR.

[PMID 17900590] C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

[PMID 17903293OA-icon.png] Genome-wide association with select biomarker traits in the Framingham Heart Study.

[PMID 18162041OA-icon.png] Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

[PMID 18167554OA-icon.png] C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

[PMID 18216863OA-icon.png] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

[PMID 18285551OA-icon.png] Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.

[PMID 18394581OA-icon.png] Bayesian meta-analysis of genetic association studies with different sets of markers.

[PMID 18704199OA-icon.png] Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

[PMID 18714384OA-icon.png] The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

[PMID 18793001OA-icon.png] Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

[PMID 19076828OA-icon.png] Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

[PMID 19095725OA-icon.png] Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

[PMID 19262552OA-icon.png] C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.

[PMID 19272152OA-icon.png] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19336475OA-icon.png] Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

[PMID 19410251] Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

[PMID 19426506OA-icon.png] C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

[PMID 19436291OA-icon.png] C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.

[PMID 19545442OA-icon.png] Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.

[PMID 19567438OA-icon.png] Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

[PMID 19946607OA-icon.png] Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.

[PMID 20031577OA-icon.png] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

[PMID 20494378] Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.

[PMID 20616999OA-icon.png] Usefulness of Mendelian randomization in observational epidemiology.

[PMID 20714329OA-icon.png] C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.

[PMID 21034294] C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

[PMID 21496483] Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.

[PMID 21647738OA-icon.png] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

[PMID 21773944] Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.

[PMID 21979869OA-icon.png] C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

[PMID 22875596] Association study of CRP gene and ischemic stroke in a Chinese Han population

[PMID 23940726OA-icon.png] Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an american Indian population

[PMID 24135623] C-reactive protein polymorphism rs3091244 is associated with abdominal aortic aneurysm

[PMID 24762112] Increased body mass index, elevated C-reactive protein, and short telomere length

[PMID 25025473OA-icon.png] Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk

[PMID 29379005OA-icon.png] Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China.

[PMID 29556849] C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population.

[PMID 32311164OA-icon.png] Association between C-reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty.