Osteoarthritis, characterized by degeneration of articular cartilage, is the most common form of arthritis and a major concern for aging societies worldwide. Wikipedia
Heritability of severe osteoarthritis is approximately 30%, according to this 2003 report [PMID 12855031].
SNPs in various genes appear to be associated with osteoarthritis:
- rs143383 (risk allele T) [PMID 19479880]
- rs11842874 (risk allele G) 10.1016/j.ajhg.2011.08.001
[PMID 17195216] osteoarthritis - Sex and ethnic differences related to snps
[PMID 17704066] Multi-SNP model for estimating risk of osteoarthritis in both men and women