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From SNPedia

Geno Mag Summary
(C;C) 2 1.8 times higher odds of having chronic hepatitis B
(T;T) 0 common in complete genomics
Make rs3077(C;T)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (old)rs3077
1000 genomesrs3077
23andMe allrs3077
SNP Nexus

GWAS Ctlgrs3077
Max Magnitude2
? (C;C) (C;T) (T;T) 28

23andMe blog rs3077(A) and rs9277535(A) may reduce risk of Hepatitis B infection

[PMID 21346778OA-icon.png] Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver

[PMID 21750111] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population

[PMID 22363396OA-icon.png] HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B

[PMID 22448225OA-icon.png] A Common HLA-DPA1 Variant Is Associated with Hepatitis B Virus Infection but Fails to Distinguish Active from Inactive Caucasian Carriers

[PMID 22543033] Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: Case-control study and meta-analysis

[PMID 22536334OA-icon.png] A Genome-Wide Homozygosity Association Study Identifies Runs of Homozygosity Associated with Rheumatoid Arthritis in the Human Major Histocompatibility Complex

[PMID 22105689] Genetic variants in HLA-DP/DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.

[PMID 22737229OA-icon.png] Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean

[PMID 20436909OA-icon.png] The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data.

[PMID 21310144] Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.

[PMID 21402545OA-icon.png] A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.

[PMID 21408128OA-icon.png] Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.

[PMID 23326374OA-icon.png] Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients

GWAS snp
PMID [PMID 23760081]
Trait Chronic hepatitis B infection
Title A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
Risk Allele
P-val 5E-39
Odds Ratio 1.89 [1.69-2.08]

[PMID 24465836OA-icon.png] Genetic association of human leukocyte antigens with chronicity or resolution of hepatitis B infection in thai population

[PMID 23428460] Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.

[PMID 23449268] HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.

[PMID 23601003] Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.

[PMID 24897020OA-icon.png] Genetic Variants in Human Leukocyte Antigen-DP Influence Both Hepatitis C Virus Persistence and Hepatitis C Virus F Protein Generation in the Chinese Han Population

[PMID 25802187] Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B

[PMID 25449085] [Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection]

[PMID 25376093OA-icon.png] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children

[PMID 26387494] A randomized clinical trial of peginterferon alpha-2b with or without entecavir in patients with HBeAg-negative chronic hepatitis B: Role of host and viral factors associated with treatment response

[PMID 26634522] Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis.

[PMID 27252704OA-icon.png] Relevance of HLA-DP/DQ and ICAM-1 SNPs among Ovarian Cancer Patients.

[PMID 27394003] Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.

[PMID 28094303OA-icon.png] Genetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population.

[PMID 28267888] Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population.