rs9277535
| Orientation | plus |
| Stabilized | plus |
| Make rs9277535(A;A) |
| Make rs9277535(A;G) |
| Make rs9277535(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 33087084 |
| Gene | HLA-DPB1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs9277535 |
| dbSNP (classic) | rs9277535 |
| ClinGen | rs9277535 |
| ebi | rs9277535 |
| HLI | rs9277535 |
| Exac | rs9277535 |
| Gnomad | rs9277535 |
| Varsome | rs9277535 |
| LitVar | rs9277535 |
| Map | rs9277535 |
| PheGenI | rs9277535 |
| Biobank | rs9277535 |
| 1000 genomes | rs9277535 |
| hgdp | rs9277535 |
| ensembl | rs9277535 |
| geneview | rs9277535 |
| scholar | rs9277535 |
| rs9277535 | |
| pharmgkb | rs9277535 |
| gwascentral | rs9277535 |
| openSNP | rs9277535 |
| 23andMe | rs9277535 |
| SNPshot | rs9277535 |
| SNPdbe | rs9277535 |
| MSV3d | rs9277535 |
| GWAS Ctlg | rs9277535 |
| GMAF | 0.3264 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
23andMe blog rs3077(A) and rs9277535(A) may reduce risk of Hepatitis B infection
| GWAS snp | |
|---|---|
| PMID | [PMID 19349983] |
| Trait | Hepatitis B |
| Title | A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians |
| Risk Allele | G |
| P-val | 6E-39 |
| Odds Ratio | |
[PMID 21346778
] Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver
[PMID 21750111] A Genome-Wide Association Study of Chronic Hepatitis B Identified Novel Risk Locus in a Japanese Population
| GWAS snp | |
|---|---|
| PMID | [PMID 21764829] |
| Trait | |
| Title | A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. |
| Risk Allele | |
| P-val | 3E-12 |
| Odds Ratio | 1.3900 [1.23-1.59] |
[PMID 21904616] Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study
[PMID 22543033] Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: Case-control study and meta-analysis
[PMID 22448225] A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers
[PMID 22807686] GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers
[PMID 19458352] Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
[PMID 20436909] The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data.
[PMID 20639879] Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
[PMID 21310144] Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.
[PMID 21408128] Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.
[PMID 22105689] Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.
[PMID 22496224] A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.
| GWAS snp | |
|---|---|
| PMID | [PMID 22737229]
|
| Trait | |
| Title | Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean. |
| Risk Allele | G |
| P-val | 2E-21 |
| Odds Ratio | 1.6400 None |
[PMID 23326374] Host genetic factors affecting spontaneous HBsAg seroclearance in chronic hepatitis B patients
| GWAS snp | |
|---|---|
| PMID | [PMID 23760081] |
| Trait | Chronic hepatitis B infection |
| Title | A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. |
| Risk Allele | |
| P-val | 4E-40 |
| Odds Ratio | 1.89 [1.72-2.08] |
[PMID 23428460] Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.
[PMID 23601003] Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.
| GWAS snp | |
|---|---|
| PMID | [PMID 24940741]
|
| Trait | Chronic hepatitis B infection |
| Title | A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese. |
| Risk Allele | G |
| P-val | 5E-14 |
| Odds Ratio | 1.59 [1.41-1.79] |
[PMID 25802187] Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B
[PMID 25449085] [Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection]
[PMID 25376093] Association between single-nucleotide polymorphisms and early spontaneous hepatitis B virus e antigen seroconversion in children
[PMID 26634522] Relationship between HLA-DP gene polymorphisms and the risk of hepatocellular carcinoma: a meta-analysis.
[PMID 27291710] Association of human leukocyte antigen DP/DQ gene polymorphisms with chronic hepatitis B in Chinese Han and Uygur populations.
[PMID 27394003] Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.
[PMID 27595289] Novel HLA-DP region susceptibility loci associated with severe acute GvHD.
[PMID 28094303] Genetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population.
[PMID 29476350] Genetic polymorphism of rs9277535 in HLA-DP associated with rheumatoid arthritis and anti-CCP production in a Chinese population.
[PMID 29467950] Genetic polymorphisms in HLA-DP and STAT4 are associated with IgA nephropathy in a Southwest Chinese population.
[PMID 30471179] Association of HLA-DPA1 and HLA-DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians.
