| In Japanese, 2.4x risk of prostate cancer, 1.7x increased risk of BPH, and 1.5x increased risk of developing metastatic prostate cancer |
| Geno
|
Mag
|
Summary
|
| (A;A)
|
1
|
Normal risk of developing prostate cancer, BPH, and metastatic prostate cancer
|
| (A;G)
|
|
In Japanese, 2.4x risk of prostate cancer, 1.7x increased risk of BPH, and 1.5x increased risk of developing metastatic prostate cancer
|
| (G;G)
|
3
|
In Japanese, 6.2x increased risk of developing prostate cancer, a 3x increased risk of developing BPH, and a 5.5x increased risk of developing metastatic prostate cancer
|
For the rs2011077 polymorphism, a significant increased risk of prostate cancer was found in men with the GG genotype (aOR = 6.260, 95% CI = 3.152–12.433, p < 0.001) or the GA genotype (aOR = 2.497, 95% CI = 1.717–3.630, p < 0.001) compared with the AA genotype. When GG, GA and AA genotypes were valued as 2, 1 and 0, respectively, the presence of the G allele was shown to increase the risk of prostate cancer with a gene dosage effect (aOR = 2.500, 95% CI = 1.871–3.339, p < 0.001). As for BPH, a significantly increased risk was found in the GG genotype (aOR = 3.033, 95% CI = 1.352–6.807, p = 0.007) and the GA genotype (aOR = 1.700, 95% CI = 1.077–2.683, p = 0.023) compared with the AA genotype. When GG, GA and AA genotypes were valued as 2, 1 and 0, respectively, the presence of the G allele was shown to increase the risk of BPH with a gene dosage effect (aOR = 1.724, 95% CI = 1.218–2.441, p = 0.002).
