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From SNPedia

risk of colon cancer
Is agenotype
Merged fromRs137854579, Rs28933380
Geno Mag Summary
(A;A) 3 risk of colon cancer and familial adenomatous polyposis (FAP) which usually progresses to malignancy
(A;T) 2.7 risk of colon cancer
(T;T) 0 common in complete genomics

Also known as rs28933380 related to colorectal cancer, FAMILIAL, Ashkenazi
See discussion at: Rs1801155

The APC I1307K mutation is primarily found in people of Ashkenazi Jewish heritage (Jews of Eastern European or Russian ancestry). Researchers believe that 6% of Ashkenazi Jews carry this gene mutation, making them at a significantly higher risk for developing colorectal cancer. It is also found among Sephardi and Mizrahi Jews and Muslim and Christian Palestinian Arabs, as well as Negev Bedouin.

Many patients with colorectal cancer experience no symptoms in the early stages. In fact, symptoms may not appear until the disease is in advanced stage. Routine colorectal screening is very important. Even children from 11 years of age should be screened if there is a family history of colorectal cancer.