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From SNPedia

Geno Mag Summary
(C;C) 1.5 slightly increased risk for abdominal aortic aneurysm reported
(G;G) 0 common in complete genomics
ReferenceGRCh38 38.1/141
GeneIL6, LOC541472
is asnp
is mentioned by
dbSNP (classic)rs1800796
1000 genomesrs1800796
GWAS Ctlgrs1800796
Max Magnitude1.5
? (C;C) (C;G) (G;G) 28

[PMID 17996468] rs1800796 IL-6 572G>C polymorphism (and h.211 haplotype) is associated with abdominal aortic aneurysm (AAA). The risk allele is C.

[PMID 17508011] Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.

[PMID 18257935OA-icon.png] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

[PMID 18449426] rs1800796 coronary artery disease 190 affected Asian Indian sibling pairs

[PMID 19288024] Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome.

[PMID 19435922OA-icon.png] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer

[PMID 19452524OA-icon.png] Tumor markers and rectal cancer: support for an inflammation-related pathway

[PMID 19387461OA-icon.png] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection

[PMID 20939703] The Interleukin 6 -572 G>C (rs1800796) Polymorphism Is Associated with the Risk of Developing Acute Coronary Syndrome

[PMID 20954977] Effect of IL-6 C-572G polymorphism on idiopathic membranous nephropathy risk in a han chinese population

[PMID 21137202] [Polymorphism of cytokine genes and human longevity]

[PMID 19506792] The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort

[PMID 21833041] Relationship of Plasma Interleukin-6 and Its Genetic Variants With Hypertension in Hong Kong Chinese

[PMID 22107760OA-icon.png] Genetic susceptibility of intervertebral disc degeneration among young Finnish adults

[PMID 22272811OA-icon.png] Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease

[PMID 22457277OA-icon.png] A Functional Single-Nucleotide Polymorphism in Interleukin-6 Promoter is associated with Susceptibility to Tuberculosis

[PMID 22677780] Interleukin-6 -634G>C Genetic Polymorphism Is Associated with Prognosis following Surgery for Advanced Thoracic Esophageal Squamous Cell Carcinoma

[PMID 22695063OA-icon.png] Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain

[PMID 22701584OA-icon.png] IL-6-174 G/C and -572 C/G Polymorphisms and Risk of Alzheimer’s Disease

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 15981030] Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 17003362] IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies.

[PMID 17416766] IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States.

[PMID 17594514OA-icon.png] Active and passive smoking, IL6, ESR1, and breast cancer risk.

[PMID 17694420OA-icon.png] IL6 genotypes and colon and rectal cancer.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 17785926] Effects of the Interaction between Interleukin-6 -634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations.

[PMID 18216863OA-icon.png] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

[PMID 18239642OA-icon.png] Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.

[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.

[PMID 18321738] Is the interleukin-6 haplotype a prognostic factor for sciatica?

[PMID 18436879OA-icon.png] Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study.

[PMID 18496509OA-icon.png] An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.

[PMID 18500540OA-icon.png] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18992263OA-icon.png] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.

[PMID 19124510OA-icon.png] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19230157OA-icon.png] Immunogenetics of seasonal influenza vaccine response.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19267250OA-icon.png] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

[PMID 19272152OA-icon.png] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19503017OA-icon.png] Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.

[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19729864OA-icon.png] Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.

[PMID 19942621OA-icon.png] An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.

[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

[PMID 20031584OA-icon.png] Genetics of atherothrombotic and lacunar stroke.

[PMID 20059469OA-icon.png] Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study.

[PMID 20144192OA-icon.png] Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.

[PMID 20565774OA-icon.png] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

[PMID 20585578OA-icon.png] The interaction between coagulation factor 2 receptor and interleukin 6 haplotypes increases the risk of myocardial infarction in men.

[PMID 20667498] The interleukin-6 gene -572C/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers.

[PMID 21536090] Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis.

[PMID 23088295] A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels

[PMID 23569034] Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation

[PMID 23881440] Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population

[PMID 23415255] Association of Interleukin 6 gene polymorphisms with genetic susceptibilities to spastic tetraplegia in males: a case-control study

[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects

[PMID 24072654] Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis

[PMID 24371367OA-icon.png] Rather than Rs1800796 Polymorphism, Expression of Interleukin-6 is Associated with Disease Progression of Chronic HBV Infection in a Chinese Han Population

[PMID 24530755] Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population

[PMID 22579472] The IL6 gene polymorphism -634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women.

[PMID 22711691] Associations between interleukin-6 gene -174 C/G and -572 C/G polymorphisms and the risk of gastric cancer: a meta-analysis.

[PMID 22714907] IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.

[PMID 23289913] Association between the interleukin-6 gene -572 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjects.

[PMID 24903966OA-icon.png] The association between sex-related interleukin-6 gene polymorphisms and the risk for cerebral palsy

[PMID 23991193OA-icon.png] Novel single nucleotide polymorphisms in interleukin 6 affect tacrolimus metabolism in liver transplant patients

[PMID 25325233] Linkage and Association Between Interleukin-6 Gene Polymorphisms and Ischemic Stroke: A Family-Based Study in the Northern Chinese Han Population

[PMID 25648033] IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus infection

[PMID 25735143] [Combinations of cytokine gene network polymorphic markers as potential predictors of myocardial infarction]

[PMID 25802725OA-icon.png] Response to the dipeptidyl peptidase-4 inhibitors in Japanese patients with type 2 diabetes might be associated with a diplotype of two single nucleotide polymorphisms on the interleukin-6 promoter region under a certain level of physical activity

[PMID 24782217] Role of inflammatory parameters in the susceptibility of cerebral thrombosis

[PMID 25305747OA-icon.png] IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort

[PMID 25299085] IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population

[PMID 26191285OA-icon.png] Gene polymorphism of IL-6 and MMP-3 decreases passive range of motion after rotator cuff repair

[PMID 26447433] IL6 gene allele-specific C/EBPα-binding activity affects the development of HBV infection through modulation of Th17/Treg balance

[PMID 25603974] Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case-control study in adults with severe osteoarthritis

[PMID 26535637] Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis

[PMID 26535651] Role of interleukin-6 gene polymorphisms in the development of prostate cancer

[PMID 26813132] [Association of single nucleotide polymorphisms of IL-6 gene with longevity in Uyghurs in Xinjiang].

[PMID 27476361] Genetic and clinical risk factors of root resorption associated with orthodontic treatment.

[PMID 28268030] Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study.

[PMID 28593468] Association of the IL6 rs1800796, but not of the IL6 rs1800795, IL6R rs4845617 and rs2228145 polymorphisms with hip fracture in elderly Mexican women.

[PMID 28716248OA-icon.png] Interleukin-6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous West African Men.

[PMID 28763918] [The association between single-nucleotide polymorphisms in IL6, IL10 genes and the susceptibility to primary hepatic carcinoma in Shunde District of Foshan City].

[PMID 28860542OA-icon.png] Genetic association study of common variants in TGFB1 and IL-6 with developmental dysplasia of the hip in Han Chinese population.

[PMID 29042807OA-icon.png] Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: influence of interleukin-6/6R gene polymorphisms on inflammatory markers.

[PMID 30795743OA-icon.png] Association of a placental Interleukin-6 genetic variant (rs1800796) with DNA methylation, gene expression and risk of acute chorioamnionitis.

[PMID 31288714] Polymorphisms of the Highly Expressed IL-6 Gene in the Papillary Thyroid Cancer Susceptibility Among Chinese.

[PMID 31301734OA-icon.png] Impact of interleukin-6 gene polymorphisms and its interaction with obesity on osteoporosis risk in Chinese postmenopausal women.

[PMID 31900992] Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population.

[PMID 32046104OA-icon.png] The Impact of IL-6 and IL-10 Gene Polymorphisms in Diffuse Large B-Cell Lymphoma Risk and Overall Survival in an Arab Population: A Case-Control Study.

[PMID 33359288] Polymorphisms in the IL-6 and TNF-α gene are associated with an increased risk of abdominal aortic aneurysm.