|| 1.3x higher risk for Crohn's disease
|| 1.9x higher risk for Crohn's disease
|?|| (C;C) (C;G) (G;G) ||28|
has been reported in a large study to be associated with Crohn's disease
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.29 (CI 1.13-1.46), and for homozygotes, 1.92 (CI 1.58-2.34). [PMID 17554300]
|Desc||NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN PROTEIN 2; NOD2|
] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18843111] Individual disease risk and multimetric analysis of Crohn disease.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 28506689] Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice.