rs1205

plus

Geno	Mag	Summary
(C;T)	0	common in complete genomics

Make rs1205(C;C)

Make rs1205(T;T)

Reference

GRCh38 38.1/141

Chromosome

1

Position

159712443

Gene

CRP

is a	snp
is	mentioned by
dbSNP	rs1205
dbSNP (classic)	rs1205
ClinGen	rs1205
ebi	rs1205
HLI	rs1205
Exac	rs1205
Gnomad	rs1205
Varsome	rs1205
LitVar	rs1205
Map	rs1205
PheGenI	rs1205
Biobank	rs1205
1000 genomes	rs1205
hgdp	rs1205
ensembl	rs1205
geneview	rs1205
scholar	rs1205
google	rs1205
pharmgkb	rs1205
gwascentral	rs1205
openSNP	rs1205
23andMe	rs1205
SNPshot	rs1205
SNPdbe	rs1205
MSV3d	rs1205
GWAS Ctlg	rs1205

GMAF

0.365

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

Although somewhat lacking in statistical power, several reports have linked rs1205, a UTR mutation known as CRP4 in the C-reactive protein CRP to the autoimmune disorder SLE, systemic lupus erythematosus. The risk allele in dbSNP orientation is (T). [PMID 14645206, PMID 15897982]

[PMID 19139754 ] C-reactive protein (CRP) levels obesity rs1205(G) allele had significantly higher CRP levels than noncarriers in a dose-dependent manner suggesting a possible association with fat localization

23andMe blog each rs1205(T) lowered CRP by 20% but no association with heart disease.

OMIM	123260
Desc	C-REACTIVE PROTEIN, PENTRAXIN-RELATED; CRP
Variant
Related	also

[PMID 19040303] C-reactive protein gene polymorphisms in biopsy-proven giant cell arteritis from Northwestern Spain

[PMID 19433520 ] Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study

OMIM	601367
Desc	STROKE, ISCHEMIC
Variant
Related	also

OMIM	152700
Desc	SYSTEMIC LUPUS ERYTHEMATOSUS; SLE
Variant
Related	also

[PMID 19101671] Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity

[PMID 19692124] Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration

[PMID 19821022] Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples

[PMID 19965533 ] CRP polymorphisms and progression of chronic kidney disease in African Americans

[PMID 20538124] Genetic Polymorphisms and the Cardiovascular Risk of Non-Steroidal Anti-Inflammatory Drugs

[PMID 20552244] Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia

[PMID 20733302] Genetic Variants in the C-Reactive Protein Gene Are Associated with Microangiopathic Ischemic Stroke

[PMID 20333461] Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population

[PMID 20856253] Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan

[PMID 20949557 ] Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival

[PMID 21293934] Association of C-reactive Protein Gene Polymorphisms and Colorectal Cancer

OMIM	613145
Desc
Variant
Related	also

[PMID 21413847] Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey

[PMID 21080913] The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study

[PMID 21575917] C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants

[PMID 22004660 ] Genetic Variants, Immune Function, and Risk of Pre-Eclampsia among American Indians

[PMID 16519819 ] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16723442 ] A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

[PMID 16733231] Association study between C-reactive protein genes and ischemic stroke in Japanese subjects.

[PMID 16820586 ] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16832152] Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

[PMID 17101857] Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey.

[PMID 17697822] Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).

[PMID 17888441 ] Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.

[PMID 17900590] C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

[PMID 17903293 ] Genome-wide association with select biomarker traits in the Framingham Heart Study.

[PMID 17956875] DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study.

[PMID 18000615] Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study.

[PMID 18162041 ] Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

[PMID 18167554 ] C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

[PMID 18216863 ] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

[PMID 18285551 ] Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.

[PMID 18385179] Systemic inflammation, genetic susceptibility and lung function.

[PMID 18394581 ] Bayesian meta-analysis of genetic association studies with different sets of markers.

[PMID 18439548 ] Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

[PMID 18500540 ] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

[PMID 18700811 ] Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.

[PMID 18704199 ] Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

[PMID 18714381 ] Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study.

[PMID 18714384 ] The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

[PMID 18793001 ] Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

[PMID 19075099] Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.

[PMID 19076828 ] Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

[PMID 19095725 ] Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

[PMID 19262552 ] C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.

[PMID 19267250 ] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

[PMID 19272152 ] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19410251] Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

[PMID 19426506 ] C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

[PMID 19436291 ] C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.

[PMID 19567438 ] Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

[PMID 19796676 ] Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.

[PMID 19906786 ] Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.

[PMID 19962488 ] Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins.

[PMID 20078877 ] Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.

[PMID 20616999 ] Usefulness of Mendelian randomization in observational epidemiology.

[PMID 20974458] Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring.

[PMID 21034294] C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

[PMID 21094359] Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily).

[PMID 21296145 ] Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms.

[PMID 21325005 ] Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

[PMID 21647738 ] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

[PMID 21790705] The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics.

[PMID 21979869 ] C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

[PMID 23212764] Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C>T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma

[PMID 23254959] Serum C-reactive protein and risk of lung cancer: a case-control study

[PMID 23267696 ] Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study

[PMID 23940726 ] Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an american Indian population

[PMID 24574329] Serum C-reactive protein (CRP) associates with lupus disease activity in the absence of measurable interferon alpha and a CRP gene variant

[PMID 24602049] Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves

[PMID 23397258] Association study of CRP gene in systemic sclerosis in European Caucasian population.

[PMID 24862635] Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E)

[PMID 24894103] Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis

[PMID 25025473 ] Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk

[PMID 25020710] P324Circadian genes in the regulation of lipids in coronary artery disease

[PMID 25043606 ] Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

[PMID 25993353] Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

[PMID 25224558 ] Association of variants in genes related to the immune response and obesity with BPH in CLUE II

[PMID 26310275] CRP 1846C>T Genetic Polymorphism Is Associated with Lymph Node Metastasis and/or Severe Lymphatic Invasion in Endometrial Cancer

[PMID 26456189] Interaction of SNP in the CRP gene and plasma fatty acid profile in inflammatory pattern: A cross-sectional population-based study

[PMID 26473826 ] Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis

[PMID 26550110 ] The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis

[PMID 26813132] [Association of single nucleotide polymorphisms of IL-6 gene with longevity in Uyghurs in Xinjiang].

[PMID 27891353 ] Association of C-Reactive Protein (rs1205) Gene Polymorphism with Susceptibility to Psoriasis in South Indian Tamils.

[PMID 28287042] Impact of CRP gene and additional gene-smoking interaction on ischemic stroke in a Chinese Han population.

[PMID 29379005 ] Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China.

[PMID 29556849] C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population.

[PMID 31500937] Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents.

[PMID 31692152] Association of plasma C-reactive protein with ischemic stroke: A Mendelian randomization study.

[PMID 32514365 ] C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women.

[PMID 33296257] The Genetic Variants -717T>C (rs2794521), 1444G>A (rs1130864), and 1846 C > T (rs1205) of CRP Gene, Their Haplotypes, and Their Association with Serum CRP Levels, Acute Coronary Syndrome, and Diabetes in Patients from Western Mexico.