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From SNPedia
Magnitude 3.5
Summary Sickle Cell Anemia carrier; malaria resistance
Criteria Gs229/criteria

Bad: You are a carrier for Sickle Cell Anemia. Consider having a partner tested to understand probabilities of your potential offspring expressing Sickle Cell Anemia.

Good: You are naturally resistant to malaria.

For this reason, Repute is intentionally Not Set.

Note some believe gs229 individuals should be identified by screening before being exposed to extreme physical exertion due to ~30x higher risk for sudden death; however, the risk is still rather low - 30 per 100,000 vs 1 per 100,000.[PMID 3627196]

see also