From SNPedia
| Geno
|
Mag
|
Summary
|
| (C;C)
|
2.1
|
warfarin sensitivity (~2.5 mg/day)
|
| (G;C)
|
|
average warfarin response (~5 mg/day)
|
| (G;G)
|
2.1
|
warfarin resistance (~6.5 mg/day)
|
| ? | (C;C) (C;G) (G;G) | 28 |
|---|
 |
rs8050894, is located on chromosome 16 in the gene VKORC1. VKORC1 is the primary target of the drug warfarin (Coumadin), a commonly used oral anticoagulant. rs8050894 is one of several polymorphisms found in VKORC1 that is associated with specific warfarin doses ([PMID 15930419]). Other polymorphisms in VKORC1 (rs7196161, rs9923231, rs9934438, rs2359612) are equally predictive of warfarin dose requirement in both European and Asian-descent individuals.
Other polymorphisms found in the gene cytochrome P450 2C9 (CYP2C9) influence the metabolism of warfarin and have a smaller effect on warfarin dose. These polymorphisms are rs1799853 (CYP2C9*2) and rs1057910 (CYP2C9*3).
[PMID 18841283] In several hundred Europeans, no association was found between rs8050894 and risk for ischemic stroke.
[PMID 19436136] Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status
| PharmGKB | PA162356242 |
| Name | VKORC1: 1542G>C, 6853G>C |
| Annotation | This SNP is the tagging SNP for VKORC1*2. |
| Gene | VKORC1 |
| Featue | Intron |
| Evidence | PubMed ID:16270629 |
| Drugs | warfarin |
| Diseases | |
| Curation Level | Curated |
[PMID 21179439] VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey
