|Associated with T2D.|
|(C;C)||2||Normal (lower) risk of Type 2 Diabetes and Gestational Diabetes.|
|(C;T)||2.1||1.4x increased risk for diabetes (and perhaps colon cancer).|
|(T;T)||3.5||2x increased risk for Type-2 diabetes|
Note: this is one of two SNPs within the TCF7L2 gene that have been reported to be associated with type-2 diabetes, the other being rs4506565. They have approximately equal power to estimate risk for type-2 diabetes, and the results from one correlate 92% of the time with the other. [PMID 17554300]
Full text of the paper is available from from Plos Medicine.
Or from NCBI as [PMID 17020404].
[PMID 17668382] reconfirmed in a diverse population
[PMID 17971425] Associated in a study of ~1000 Hispanic-Americans with reduced insulin secretion as measured by acute insulin response and adjusted for the degree of insulin sensitivity (p = 0.032).
[PMID 17671651] the CT/TT genotypes strongly predicted future type-2 diabetes. The risk T allele was associated with impaired insulin secretion, incretin effects, and enhanced rate of hepatic glucose production. TCF7L2 expression in human islets was increased 5-fold in T2D, particularly in carriers of the TT genotype.
This SNP is one of 4 relatively common SNPs reported to represent risk for type-2 diabetes in the DESIR prospective study of 3,877 Caucasian participants. Under an additive model, the odds ratio for the (T) risk allele is 1.45 (CI: 1.2-1.77, p=0.0002). For the 4 SNPs, each risk allele increased type-2 diabetes risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).[PMID 17977958]
Contrary to what's been seen in most populations studied so far, the association between rs7903146 and type-2 diabetes apparently does not hold in Arab populations, based on a case-control study of 522 Saudi patients and 346 controls.[PMID 18655717]
A HuGE review and meta-analysis including over 35,000 type-2 diabetes cases and 39,000 controls concluded that the Bayesian odds ratio for rs7903146(T;T) homozygotes and (C;T) heterozygotes versus (C;C) homozygotes was 1.968 (95% credible interval (CrI): 1.790 - 2.157) and 1.406 (95% CrI: 1.341 - 1.476), respectively, and the population attributable risk (PAR) for the (C;T)/(T;T) genotypes of this variant is 16.9% overall. Along with 3 other TCF7L2 SNPs, a multiplicative genetic model was indicated.[PMID 19228405]
A study of over 13,000 individuals initially free of cancer and followed over 10+ years found that the rs7903146(T) allele was associated with increased risk of colorectal cancer, with an adjusted odds ratio of 1.25 (CI:0.85-1.83) and 2.15 (CI:1.27-3.64) for the (C;T) and (T;T) genotypes, respectively.[PMID 18268068]
Does the association with type 2 diabetes hold for youth as well as for adults? Among African American youth, each copy of a rs7903146(T) allele was associated with a 1.97-fold (CI:1.37 - 2.82) increased odds for type 2 diabetes (p?<?0.0001), yet no significant association was detected in non-Hispanic white youth (adjusted odds ratio 1.14; CI: 0.73 - 1.79).[PMID 21109996]
[PMID 19258437] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.
[PMID 18555673] The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects
|Trait||Type 2 diabetes|
|Title||Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data|
|Odds Ratio||1.49 [1.39-1.59]|
|Trait||Type 2 diabetes|
|Title||Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes|
|Odds Ratio||1.37 [1.28-1.47]|
|Trait||Type 2 diabetes|
|Title||Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels|
|Odds Ratio||1.37 [1.31-1.43]|
|Trait||Type 2 diabetes|
|Title||A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants|
|Odds Ratio||1.37 [1.31-1.43]|
|Trait||Type 2 diabetes|
|Title||A variant in CDKAL1 influences insulin response and risk of type 2 diabetes|
|Odds Ratio||1.38 [NR]|
|Trait||Type 2 diabetes|
|Title||A genome-wide association study identifies novel risk loci for type 2 diabetes|
|Odds Ratio||1.65 [1.28, 2.02]|
|Trait||Type 2 diabetes|
|Title||Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population|
|Odds Ratio||1.54 [1.36-1.74]|
[PMID 18972257] Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study
[PMID 18996470] Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes
[PMID 19473183] Interactions between TCF7L2 genotype and growth hormone-induced changes in glucose homeostasis in small for gestational age children
[PMID 19509102] Genetic Variants of TCF7L2 are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults
[PMID 19533015] Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)
[PMID 19183934] TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study
[PMID 19573884] No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort
[PMID 19585101] A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis[PMID 19713311] TCF7L2 Polymorphism Associates with New-Onset Diabetes after Transplantation
|Trait||Type 2 diabetes and other traits|
|Title||Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia|
|Odds Ratio||1.48 [1.39-1.57]|
[PMID 19864407] Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention
[PMID 19924244] TCF7L2 Polymorphism rs7903146 Is Associated with Coronary Artery Disease Severity and Mortality
[PMID 20028944] Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a risk population for type 2 diabetes
[PMID 20041287] Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome
[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
[PMID 20097709] Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans
[PMID 20437825] Relationship of five type 2 diabetes candidate gene polymorphisms to the age at diagnosis of diabetes in the Slovakian population
[PMID 20503258] Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City
[PMID 20546291] Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5)
[PMID 19806338] TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance
[PMID 20578204] Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC) study
[PMID 20597906] A Validation Study of Type 2 Diabetes-related Variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ Genes in one Endogamous Ethnic Group of North India
|Trait||Type 2 diabetes|
|Title||Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis|
|Odds Ratio||1.40 [1.34-1.46]|
[PMID 20682688] Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and post-challenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes from the International Association of Diabetes and Pregnancy Study Groups
[PMID 20802253] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
[PMID 20839289] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
|Title||A genome-wide association study of the metabolic syndrome in Indian Asian men|
|Odds Ratio||1.33 [1.19-1.49]|
|Title||The TCF7L2 Diabetes Risk Variant is Associated with HbA(1C) Levels: a Genome-Wide Association Meta-Analysis|
|Odds Ratio||0.05 [0.02-0.08] % HbA1C decrease|
[PMID 20980453] Re-sequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests the SNP rs7903146 is the Causal Diabetes Susceptibility Variant
[PMID 21301999] Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters
[PMID 21414605] At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia
[PMID 21543200] Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome
[PMID 21641671] Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients
[PMID 21678030] Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population
[PMID 22052079] Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
[PMID 22109281] The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study
[PMID 21749608] Genetic variants and the metabolic syndrome: a systematic review
[PMID 22275441] Genetic risk assessment of type 2 diabetes-associated polymorphisms in african americans
|Title||Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.|
|Odds Ratio||1.4600 None|
|Title||Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.|
|Odds Ratio||None None|
[PMID 22402060] Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes
[PMID 22419714] Effect of Type 2 Diabetes Predisposing Genetic Variants on Colorectal Cancer Risk
[PMID 22441719] Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population
[PMID 22569928] Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
[PMID 22590553] An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers
[PMID 21399856] Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians
[PMID 22712642] TCF7L2 polymorphism and cognitive test performance in cardiovascular disease
[PMID 16936215] Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
[PMID 16936217] Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.
[PMID 16936218] Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
[PMID 17003358] Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.
[PMID 17003360] Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
[PMID 17031610] Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
[PMID 17065361] TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.
[PMID 17093941] Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.
[PMID 17130514] Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.
[PMID 17181866] Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.
[PMID 17206141] Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.
[PMID 17226113] Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys.
[PMID 17245589] A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
[PMID 17259383] Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.
[PMID 17311858] TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.
[PMID 17340123] Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.
[PMID 17342473] A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
[PMID 17416797] TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.
[PMID 17429603] TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.
[PMID 17437080] Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.
[PMID 17470138] Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City.
[PMID 17476472] TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.
[PMID 17503332] Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
[PMID 17579206] Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population.
[PMID 17593304] TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population.
[PMID 17601994] Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.
[PMID 17609304] Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.
[PMID 17618413] Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.
[PMID 17661009] Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.
[PMID 17683561] The TCF7L2 locus and type 1 diabetes.
[PMID 17697858] The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.
[PMID 17725629] The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
[PMID 17786212] Heterogeneity in meta-analyses of genome-wide association investigations.
[PMID 17805508] Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS.
[PMID 17903298] Genome-wide association with diabetes-related traits in the Framingham Heart Study.
[PMID 17934151] A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.
[PMID 17972059] TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.
[PMID 18097733] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18248681] Prevalence of common disease-associated variants in Asian Indians.
[PMID 18282109] Adaptations to climate in candidate genes for common metabolic disorders.
[PMID 18282631] Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.
[PMID 18291022] Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.
[PMID 18310307] Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.
[PMID 18319073] Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes.
[PMID 18335027] Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.
[PMID 18397358] TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels.
[PMID 18398040] Transcription factor 7-like 2 polymorphism and colon cancer.
[PMID 18423522] Estimating odds ratios in genome scans: an approximate conditional likelihood approach.
[PMID 18437354] TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.
[PMID 18443202] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
[PMID 18461161] Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
[PMID 18469204] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
[PMID 18481957] TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells.
[PMID 18493736] Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population.
[PMID 18498634] The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.
[PMID 18498660] Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.
[PMID 18546086] TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children.
[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
[PMID 18591388] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
[PMID 18598350] Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
[PMID 18611970] Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.
[PMID 18650481] TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.
[PMID 18654633] Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies.
[PMID 18654799] Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease.
[PMID 18678618] Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.
[PMID 18689695] Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).
[PMID 18689899] Exchangeable models of complex inherited diseases.
[PMID 18694974] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
[PMID 18706099] TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.
[PMID 18712344] Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.
[PMID 18762805] Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity indices in overweight children and adolescents during a lifestyle intervention.
[PMID 18782870] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
[PMID 18839133] Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 18931037] Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study.
[PMID 18958766] Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic ovary syndrome.
[PMID 18992263] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
[PMID 19008344] Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
[PMID 19012045] Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects.
[PMID 19020323] Genotype score in addition to common risk factors for prediction of type 2 diabetes.
[PMID 19033397] Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.
[PMID 19050058] Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.
[PMID 19053027] Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.
[PMID 19055834] TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.
[PMID 19057525] Association analyses between type 2 diabetes genes and obesity traits in pigs.
[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
[PMID 19149908] Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk.
[PMID 19161620] An open access database of genome-wide association results.
[PMID 19169495] Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility.
[PMID 19172244] The risk allele load accelerates the age-dependent decline in beta cell function.
[PMID 19247628] Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.
[PMID 19286335] TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia.
[PMID 19288077] The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.
[PMID 19324937] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
[PMID 19341491] Genome-based prediction of common diseases: methodological considerations for future research.
[PMID 19351735] Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.
[PMID 19368707] Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.
[PMID 19369405] Linkage analysis of albuminuria.
[PMID 19455305] No association of multiple type 2 diabetes loci with type 1 diabetes.
[PMID 19460916] Genetic architecture of type 2 diabetes: recent progress and clinical implications.
[PMID 19482368] Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.
[PMID 19497595] Genetic variation of FTO and TCF7L2 in premature adrenarche.
[PMID 19502414] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight.
[PMID 19602480] Tissue-specific alternative splicing of TCF7L2.
[PMID 19615048] Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies.
[PMID 19643578] Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder.
[PMID 19725958] The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population.
[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
[PMID 19750184] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.
[PMID 19789636] Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.
[PMID 19825152] TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate.
[PMID 19862325] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
[PMID 19885641] Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population.
[PMID 19913122] ATRIUM: testing untyped SNPs in case-control association studies with related individuals.
[PMID 19934000] TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.
[PMID 19956539] How many genetic variants remain to be discovered?
[PMID 20017978] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
[PMID 20018041] The effect of multiple genetic variants in predicting the risk of type 2 diabetes.
[PMID 20032493] TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 20049090] Association between type 2 diabetes loci and measures of fatness.
[PMID 20081857] Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
[PMID 20092643] Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).
[PMID 20107109] The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.
[PMID 20118932] A map of open chromatin in human pancreatic islets.
[PMID 20142250] Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.
[PMID 20144318] A strategy for analyzing gene-nutrient interactions in type 2 diabetes.
[PMID 20144327] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
[PMID 20161033] Personalized pharmacotherapy for Type 2 diabetes mellitus.
[PMID 20161779] Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
[PMID 20299486] Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort.
[PMID 20361036] Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.
[PMID 20424228] Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.
[PMID 20470430] Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study.
[PMID 20478041] The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study.
[PMID 20532014] The epidemiology of diabetes in Korea: from the economics to genetics.
[PMID 20540670] Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population.
[PMID 20550665] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
[PMID 20648057] Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 20957343] Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.
[PMID 21115178] Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study.
[PMID 21159844] Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 21283728] Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
[PMID 21347282] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
[PMID 21349175] TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes.
[PMID 21384500] Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.
[PMID 21423583] Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.
[PMID 21437630] Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.
[PMID 21441683] Screening with OGTT alone or in combination with the Indian diabetes risk score or genotyping of TCF7L2 to detect undiagnosed type 2 diabetes in Asian Indians.
[PMID 21672010] Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.
[PMID 21834909] A replication study of the IRS1, CAPN10, TCF7L2, and PPARG gene polymorphisms associated with type 2 diabetes in two different populations of Mexico.
[PMID 21898192] Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.
[PMID 21965303] Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.
[PMID 22377714] Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea.
[PMID 22461567] Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.
[PMID 22552033] Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain.
[PMID 22583123] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.
|Title||Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.|
|Odds Ratio||1.2600 None|
|Title||A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.|
|Odds Ratio||None None|
[PMID 23014255] Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters
[PMID 23041303] Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population
|qualified_impact||Insufficiently evaluated pathogenic|
|summary||associated with colorectal cancer for the T allele.|
[PMID 23193183] Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study
[PMID 23249316] Genetic susceptibility to type 2 diabetes: a global meta-analysis studying the genetic differences in tunisian populations
[PMID 23029294] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus
[PMID 23527042] Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups
[PMID 23536853] Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population
|Trait||Type 2 diabetes|
|Title||Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India.|
|Odds Ratio||1.15 [1.12 - 1.17]|
[PMID 23311683] Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population
|Trait||Type 2 diabetes|
|Title||Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21.|
|Odds Ratio||1.51 [1.42-1.62]|
[PMID 23577093] Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India
[PMID 23690305] Genetic variants and the risk of gestational diabetes mellitus: a systematic review
[PMID 22749234] Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs
[PMID 23188737] TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects
[PMID 23926018] [Study of the association between SNP rs7903146(C/T) in TCF7L2 and metabolic syndrome in Chinese Korean and Han populations from Yanbian]
[PMID 23942764] Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts
[PMID 23942586] Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled trial in a high-cardiovascular-risk population
[PMID 24157263] Polymorphisms of Transcription Factor-7-Like 2 (TCF7L2) gene in Tunisian women with polycystic ovaries syndrome (PCOS)
[PMID 24371822] IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population
[PMID 24435973] Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population
[PMID 24498581] Role of the single nucleotide polymorphism rs7903146 of TCF7L2 in inducing nonsense-mediated decay
[PMID 24529562] Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration
[PMID 24574000] Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients
[PMID 22480428] T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition.
[PMID 22782288] Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.
[PMID 22843023] TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.
[PMID 22862926] Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.
[PMID 22872755] Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk.
[PMID 22911383] TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals.
[PMID 22923468] Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
[PMID 22936689] Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses.
[PMID 22996130] From mice to humans.
[PMID 23010200] Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population: a meta-analysis.
[PMID 23011354] In vitro scan for enhancers at the TCF7L2 locus.
[PMID 23034957] TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention.
[PMID 23085767] Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.
[PMID 23107111] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
[PMID 23142382] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects.
[PMID 23334806] Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
[PMID 23434931] TCF7L2 variation and proliferative diabetic retinopathy.
[PMID 23458876] ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
[PMID 23462794] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
[PMID 23855352] Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7L2) gene with gestational diabetes mellitus: a meta-analysis.
[PMID 24864085] Is TCF7L2 variant associated with non-diabetic chronic kidney disease progression? Results of a family-based study
[PMID 24906949] Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin
[PMID 24925104] Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146
[PMID 25058603] Differential transcriptional and post-translational Transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients
|Trait||Type 2 diabetes|
|Title||Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.|
|Odds Ratio||1.37 [1.27-1.48]|
[PMID 25185411] Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes in an Iranian Kurdish ethnic group
[PMID 25224167] Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients
|Trait||Type 2 diabetes|
|Title||Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.|
|Odds Ratio||1.40 [1.35-1.46]|
|Trait||Type 2 diabetes|
|Title||Genome-wide association study identifies three novel loci for type 2 diabetes.|
|Odds Ratio||1.48 [1.34-1.63]|
[PMID 25491720] The TCF7L2 rs7903146 polymorphism, dietary intakes and type 2 diabetes risk in an Algerian population
|Disease||Diabetes mellitus type 2|
|CLNDBN||Diabetes mellitus type 2|
|CLNSRC||ClinVar OMIM Allelic Variant|
[PMID 25678248] Association between rs7903146 and rs12255372 polymorphisms of transcription factor 7-like 2 gene and polycystic ovary syndrome: a systematic review and meta-analysis
[PMID 25737773] Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation
[PMID 25934528] Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with impaired proinsulin conversion-A meta-analysis
[PMID 26109524] Role of high-risk variants in the development of impaired glucose metabolism was modified by birth weight in Han Chinese
[PMID 25299103] Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil