Rs7903146

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Associated with T2D.
Orientationplus
Geno Mag Summary
(C;C) 2 Normal (lower) risk of Type 2 Diabetes and Gestational Diabetes.
(C;T) 2.1 1.4x increased risk for diabetes (and perhaps colon cancer).
(T;T) 3.5 2x increased risk for Type-2 diabetes
ReferenceGRCh38 38.1/141
Chromosome10
Position112998590
GeneTCF7L2
is asnp
is mentioned by
dbSNPrs7903146
Exacrs7903146
PheGenIrs7903146
nextbiors7903146
hapmaprs7903146
1000 genomesrs7903146
hgdprs7903146
ensemblrs7903146
gopubmedrs7903146
geneviewrs7903146
scholarrs7903146
googlers7903146
pharmgkbrs7903146
gwascentralrs7903146
openSNPrs7903146
23andMers7903146
23andMe allrs7903146
SNP Nexus

SNPshotrs7903146
SNPdbers7903146
MSV3drs7903146
GMAF0.2181
Max Magnitude3.5
? (C;C) (C;T) (T;T) 28
This SNP in TCF7L2 influences the risk of Type-2 diabetes (T2D). This SNP is also known as IVS3C>T.

[PMID 17671651OA-icon.png] rs7903146(C;T) rs7903146(T;T) strongly predicted future type-2 diabetes. Considered in context with rs7903146 rs12255372 rs10885406.

Note: this is one of two SNPs within the TCF7L2 gene that have been reported to be associated with type-2 diabetes, the other being rs4506565. They have approximately equal power to estimate risk for type-2 diabetes, and the results from one correlate 92% of the time with the other. [PMID 17554300OA-icon.png]

Full text of the paper is available from from Plos Medicine.

Or from NCBI as [PMID 17020404OA-icon.png].

[PMID 16855264OA-icon.png] TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.

[PMID 17668382OA-icon.png] reconfirmed in a diverse population

[PMID 17971425OA-icon.png] Associated in a study of ~1000 Hispanic-Americans with reduced insulin secretion as measured by acute insulin response and adjusted for the degree of insulin sensitivity (p = 0.032).

[PMID 17671651OA-icon.png] the CT/TT genotypes strongly predicted future type-2 diabetes. The risk T allele was associated with impaired insulin secretion, incretin effects, and enhanced rate of hepatic glucose production. TCF7L2 expression in human islets was increased 5-fold in T2D, particularly in carriers of the TT genotype.

This SNP is one of 4 relatively common SNPs reported to represent risk for type-2 diabetes in the DESIR prospective study of 3,877 Caucasian participants. Under an additive model, the odds ratio for the (T) risk allele is 1.45 (CI: 1.2-1.77, p=0.0002). For the 4 SNPs, each risk allele increased type-2 diabetes risk by 1.34x (p=2x10e-6), with an odds ratio of 2.48 (CI: 1.59-3.86) for carriers of 4 or more compared to those with one or none (risk alleles).[PMID 17977958]

Contrary to what's been seen in most populations studied so far, the association between rs7903146 and type-2 diabetes apparently does not hold in Arab populations, based on a case-control study of 522 Saudi patients and 346 controls.[PMID 18655717OA-icon.png]

A HuGE review and meta-analysis including over 35,000 type-2 diabetes cases and 39,000 controls concluded that the Bayesian odds ratio for rs7903146(T;T) homozygotes and (C;T) heterozygotes versus (C;C) homozygotes was 1.968 (95% credible interval (CrI): 1.790 - 2.157) and 1.406 (95% CrI: 1.341 - 1.476), respectively, and the population attributable risk (PAR) for the (C;T)/(T;T) genotypes of this variant is 16.9% overall. Along with 3 other TCF7L2 SNPs, a multiplicative genetic model was indicated.[PMID 19228405OA-icon.png]

A study of over 13,000 individuals initially free of cancer and followed over 10+ years found that the rs7903146(T) allele was associated with increased risk of colorectal cancer, with an adjusted odds ratio of 1.25 (CI:0.85-1.83) and 2.15 (CI:1.27-3.64) for the (C;T) and (T;T) genotypes, respectively.[PMID 18268068OA-icon.png]

Does the association with type 2 diabetes hold for youth as well as for adults? Among African American youth, each copy of a rs7903146(T) allele was associated with a 1.97-fold (CI:1.37 - 2.82) increased odds for type 2 diabetes (p?<?0.0001), yet no significant association was detected in non-Hispanic white youth (adjusted odds ratio 1.14; CI: 0.73 - 1.79).[PMID 21109996OA-icon.png]


[PMID 19258437OA-icon.png] A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.


[PMID 18555673] The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects

GWAS snp
PMID [PMID 19056611OA-icon.png]
Trait Type 2 diabetes
Title Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
Risk Allele
P-val 9E-30
Odds Ratio 1.49 [1.39-1.59]
GWAS snp
PMID [PMID 18372903OA-icon.png]
Trait Type 2 diabetes
Title Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Risk Allele T
P-val 3E-23
Odds Ratio 1.37 [1.28-1.47]
GWAS snp
PMID [PMID 17463246]
Trait Type 2 diabetes
Title Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Risk Allele T
P-val 9.9999999999999997E-49
Odds Ratio 1.37 [1.31-1.43]
GWAS snp
PMID [PMID 17463248OA-icon.png]
Trait Type 2 diabetes
Title A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Risk Allele T
P-val 9.9999999999999997E-49
Odds Ratio 1.37 [1.31-1.43]
GWAS snp
PMID [PMID 17460697]
Trait Type 2 diabetes
Title A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Risk Allele
P-val 2.0000000000000001E-10
Odds Ratio 1.38 [NR]
GWAS snp
PMID [PMID 17293876]
Trait Type 2 diabetes
Title A genome-wide association study identifies novel risk loci for type 2 diabetes
Risk Allele T
P-val 1.9999999999999999E-34
Odds Ratio 1.65 [1.28, 2.02]
GWAS snp
PMID [PMID 19401414OA-icon.png]
Trait Type 2 diabetes
Title Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
Risk Allele T
P-val 8E-12
Odds Ratio 1.54 [1.36-1.74]

[PMID 18972257] Comparison of genetic risk in three candidate genes (TCF7L2, PPARG, KCNJ11) with traditional risk factors for type 2 diabetes in a population-based study--the HUNT study

[PMID 18996470] Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes

[PMID 19473183] Interactions between TCF7L2 genotype and growth hormone-induced changes in glucose homeostasis in small for gestational age children

[PMID 19509102] Genetic Variants of TCF7L2 are Associated with Insulin Resistance and Related Metabolic Phenotypes in Taiwanese Adolescents and Caucasian Young Adults

[PMID 19533015] Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA)


[PMID 19183934OA-icon.png] TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study

[PMID 19573884OA-icon.png] No association between TCF7L2 rs7903146 and euglycemic-clamp-derived insulin sensitivity in a mixed-age cohort

[PMID 19585101OA-icon.png] A susceptibility gene for type 2 diabetes confers substantial risk for diabetes complicating cystic fibrosis

OMIM125853
DescDIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
Variant
Relatedalso
OMIM602228
DescTRANSCRIPTION FACTOR 7-LIKE 2; TCF7L2
Variant
Relatedalso
[PMID 19713311OA-icon.png] TCF7L2 Polymorphism Associates with New-Onset Diabetes after Transplantation
GWAS snp
PMID [PMID 19734900]
Trait Type 2 diabetes and other traits
Title Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
Risk Allele T
P-val 1E-30
Odds Ratio 1.48 [1.39-1.57]

[PMID 19864407] Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention


[PMID 19924244OA-icon.png] TCF7L2 Polymorphism rs7903146 Is Associated with Coronary Artery Disease Severity and Mortality


[PMID 20028944OA-icon.png] Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a risk population for type 2 diabetes

[PMID 20041287OA-icon.png] Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome

[PMID 20043145OA-icon.png] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study


[PMID 20097709OA-icon.png] Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans

[PMID 20437825] Relationship of five type 2 diabetes candidate gene polymorphisms to the age at diagnosis of diabetes in the Slovakian population

[PMID 20503258] Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City

[PMID 20546291] Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5)

[PMID 19806338] TCF7L2 genetic variants and progression to diabetes in the Chinese population: pleiotropic effects on insulin secretion and insulin resistance

[PMID 20578204OA-icon.png] Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of impaired fasting glucose in African American and Caucasian adults: the atherosclerosis risk in communities (ARIC) study

[PMID 20597906] A Validation Study of Type 2 Diabetes-related Variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ Genes in one Endogamous Ethnic Group of North India

GWAS snp
PMID [PMID 20581827OA-icon.png]
Trait Type 2 diabetes
Title Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele T
P-val 2E-51
Odds Ratio 1.40 [1.34-1.46]

[PMID 20682688OA-icon.png] Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and post-challenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes from the International Association of Diabetes and Pregnancy Study Groups

[PMID 20802253OA-icon.png] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion

[PMID 20839289OA-icon.png] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose

GWAS snp
PMID [PMID 20694148OA-icon.png]
Trait
Title A genome-wide association study of the metabolic syndrome in Indian Asian men
Risk Allele A
P-val 7E-7
Odds Ratio 1.33 [1.19-1.49]
GWAS snp
PMID [PMID 20849430]
Trait
Title The TCF7L2 Diabetes Risk Variant is Associated with HbA(1C) Levels: a Genome-Wide Association Meta-Analysis
Risk Allele C
P-val 1E-7
Odds Ratio 0.05 [0.02-0.08] % HbA1C decrease

[PMID 20980453OA-icon.png] Re-sequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests the SNP rs7903146 is the Causal Diabetes Susceptibility Variant

OMIM104210
DescALPHA-2A-ADRENERGIC RECEPTOR; ADRA2A
Variant
Relatedalso









[PMID 21301999] Genetic variations in transcription factor 7-like 2 (TCF7L2) gene: association of TCF7L2 rs12255372(G/T) or rs7903146(C/T) with breast cancer risk and clinico-pathological parameters

OMIM104210
Desc
Variant0001
Relatedalso
OMIM602228
Desc
Variant0001
Relatedalso


[PMID 21414605] At-Risk Variant in TCF7L2 for Type II Diabetes Increases Risk of Schizophrenia


[PMID 21543200] Dietary saturated fat, gender and genetic variation at the TCF7L2 locus predict the development of metabolic syndrome


[PMID 21641671] Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients


[PMID 21678030] Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population


[PMID 22052079OA-icon.png] Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs


[PMID 22109281] The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study


[PMID 21749608] Genetic variants and the metabolic syndrome: a systematic review


[PMID 22275441OA-icon.png] Genetic risk assessment of type 2 diabetes-associated polymorphisms in african americans

GWAS snp
PMID [PMID 22101970OA-icon.png]
Trait
Title Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.
Risk Allele T
P-val 2E-15
Odds Ratio 1.4600 None
GWAS snp
PMID [PMID 21873549OA-icon.png]
Trait
Title Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Risk Allele T
P-val 2E-20
Odds Ratio None None


[PMID 22402060OA-icon.png] Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes


[PMID 22419714] Effect of Type 2 Diabetes Predisposing Genetic Variants on Colorectal Cancer Risk


[PMID 22441719] Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population


[PMID 22569928OA-icon.png] Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus


[PMID 22590553OA-icon.png] An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers


[PMID 21399856] Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians


[PMID 22712642] TCF7L2 polymorphism and cognitive test performance in cardiovascular disease


[PMID 16936215] Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.


[PMID 16936217] Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample.


[PMID 16936218] Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.


[PMID 17003358] Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.


[PMID 17003360] Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.


[PMID 17031610] Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.


[PMID 17065361] TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.


[PMID 17093941] Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.


[PMID 17130514] Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women.


[PMID 17181866OA-icon.png] Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.


[PMID 17206141] Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.


[PMID 17226113] Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys.


[PMID 17245589] A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.


[PMID 17259383] Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans.


[PMID 17311858] TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.


[PMID 17340123] Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.


[PMID 17342473] A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.


[PMID 17416797OA-icon.png] TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.


[PMID 17429603] TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.


[PMID 17437080] Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion.


[PMID 17470138] Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City.


[PMID 17476472] TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.


[PMID 17503332OA-icon.png] Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.


[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.


[PMID 17579206] Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population.


[PMID 17593304OA-icon.png] TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population.


[PMID 17601994] Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.


[PMID 17609304] Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.


[PMID 17618413] Variants of the TCF7L2 gene are associated with beta cell dysfunction and confer an increased risk of type 2 diabetes mellitus in the ULSAM cohort of Swedish elderly men.


[PMID 17661009OA-icon.png] Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.


[PMID 17683561OA-icon.png] The TCF7L2 locus and type 1 diabetes.


[PMID 17697858] The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians.


[PMID 17725629] The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.


[PMID 17786212OA-icon.png] Heterogeneity in meta-analyses of genome-wide association investigations.


[PMID 17805508] Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS.


[PMID 17903298OA-icon.png] Genome-wide association with diabetes-related traits in the Framingham Heart Study.


[PMID 17934151] A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.


[PMID 17972059] TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.


[PMID 18097733] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.


[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.


[PMID 18248681OA-icon.png] Prevalence of common disease-associated variants in Asian Indians.


[PMID 18282109OA-icon.png] Adaptations to climate in candidate genes for common metabolic disorders.


[PMID 18282631] Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects.


[PMID 18291022OA-icon.png] Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.


[PMID 18310307] Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.


[PMID 18319073OA-icon.png] Using the optimal receiver operating characteristic curve to design a predictive genetic test, exemplified with type 2 diabetes.


[PMID 18335027OA-icon.png] Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP.


[PMID 18397358] TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels.


[PMID 18398040OA-icon.png] Transcription factor 7-like 2 polymorphism and colon cancer.


[PMID 18423522OA-icon.png] Estimating odds ratios in genome scans: an approximate conditional likelihood approach.


[PMID 18437354OA-icon.png] TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.


[PMID 18443202OA-icon.png] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.


[PMID 18461161OA-icon.png] Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.


[PMID 18469204OA-icon.png] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.


[PMID 18481957] TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells.


[PMID 18493736] Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population.


[PMID 18498634OA-icon.png] The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.


[PMID 18498660OA-icon.png] Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study.


[PMID 18546086] TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children.


[PMID 18556337OA-icon.png] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).


[PMID 18591388OA-icon.png] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.


[PMID 18598350OA-icon.png] Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.


[PMID 18611970] Impact of TCF7L2 rs7903146 on insulin secretion and action in young and elderly Danish twins.


[PMID 18650481OA-icon.png] TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.


[PMID 18654633OA-icon.png] Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies.


[PMID 18654799OA-icon.png] Exploration of the utility of ancestry informative markers for genetic association studies of African Americans with type 2 diabetes and end stage renal disease.


[PMID 18678618OA-icon.png] Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.


[PMID 18689695OA-icon.png] Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).


[PMID 18689899OA-icon.png] Exchangeable models of complex inherited diseases.


[PMID 18694974OA-icon.png] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.


[PMID 18706099OA-icon.png] TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes.


[PMID 18712344] Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.


[PMID 18762805] Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity indices in overweight children and adolescents during a lifestyle intervention.


[PMID 18782870OA-icon.png] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.


[PMID 18839133] Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.


[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 18931037OA-icon.png] Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study.


[PMID 18958766] Genetic variants in TCF7L2 and KCNJ11 genes in a Greek population with polycystic ovary syndrome.


[PMID 18992263OA-icon.png] Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.


[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.


[PMID 19008344OA-icon.png] Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.


[PMID 19012045] Common coding variant in the TCF7L2 gene and study of the association with type 2 diabetes in Japanese subjects.


[PMID 19020323OA-icon.png] Genotype score in addition to common risk factors for prediction of type 2 diabetes.


[PMID 19033397OA-icon.png] Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.


[PMID 19050058OA-icon.png] Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.


[PMID 19053027] Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.


[PMID 19055834OA-icon.png] TCF7L2 variant genotypes and type 2 diabetes risk in Brazil: significant association, but not a significant tool for risk stratification in the general population.


[PMID 19057525] Association analyses between type 2 diabetes genes and obesity traits in pigs.


[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.


[PMID 19149908] Whole-grain consumption and transcription factor-7-like 2 ( TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk.


[PMID 19161620OA-icon.png] An open access database of genome-wide association results.


[PMID 19169495] Allele-specific PCR assay to genotype SNP rs7903146 in TCF7L2 gene for rapid screening of diabetes susceptibility.


[PMID 19172244] The risk allele load accelerates the age-dependent decline in beta cell function.


[PMID 19247628] Unique splicing pattern of the TCF7L2 gene in human pancreatic islets.


[PMID 19286335] TCF7L2 is associated with type 2 diabetes in nonobese individuals from Tunisia.


[PMID 19288077] The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.


[PMID 19324937OA-icon.png] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.


[PMID 19341491OA-icon.png] Genome-based prediction of common diseases: methodological considerations for future research.


[PMID 19351735OA-icon.png] Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.


[PMID 19368707OA-icon.png] Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.


[PMID 19369405OA-icon.png] Linkage analysis of albuminuria.


[PMID 19455305OA-icon.png] No association of multiple type 2 diabetes loci with type 1 diabetes.


[PMID 19460916OA-icon.png] Genetic architecture of type 2 diabetes: recent progress and clinical implications.


[PMID 19482368] Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.


[PMID 19497595] Genetic variation of FTO and TCF7L2 in premature adrenarche.


[PMID 19502414OA-icon.png] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.


[PMID 19593725OA-icon.png] Association of maternally inherited GNAS alleles with African-American male birth weight.


[PMID 19602480OA-icon.png] Tissue-specific alternative splicing of TCF7L2.


[PMID 19615048OA-icon.png] Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies.


[PMID 19643578OA-icon.png] Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder.


[PMID 19725958OA-icon.png] The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population.


[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.


[PMID 19750184OA-icon.png] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.


[PMID 19789636OA-icon.png] Alternative splicing of TCF7L2 gene in omental and subcutaneous adipose tissue and risk of type 2 diabetes.


[PMID 19825152OA-icon.png] TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate.


[PMID 19862325OA-icon.png] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.


[PMID 19885641] Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population.


[PMID 19913122OA-icon.png] ATRIUM: testing untyped SNPs in case-control association studies with related individuals.


[PMID 19934000OA-icon.png] TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action.


[PMID 19956539OA-icon.png] How many genetic variants remain to be discovered?


[PMID 20017978OA-icon.png] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.


[PMID 20018041OA-icon.png] The effect of multiple genetic variants in predicting the risk of type 2 diabetes.


[PMID 20032493] TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.


[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.


[PMID 20049090OA-icon.png] Association between type 2 diabetes loci and measures of fatness.


[PMID 20081857OA-icon.png] Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.


[PMID 20092643OA-icon.png] Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).


[PMID 20107109OA-icon.png] The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.


[PMID 20118932OA-icon.png] A map of open chromatin in human pancreatic islets.


[PMID 20142250OA-icon.png] Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.


[PMID 20144318OA-icon.png] A strategy for analyzing gene-nutrient interactions in type 2 diabetes.


[PMID 20144327OA-icon.png] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.


[PMID 20161033OA-icon.png] Personalized pharmacotherapy for Type 2 diabetes mellitus.


[PMID 20161779OA-icon.png] Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.


[PMID 20299486OA-icon.png] Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort.


[PMID 20361036OA-icon.png] Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.


[PMID 20424228OA-icon.png] Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.


[PMID 20470430OA-icon.png] Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study.


[PMID 20478041OA-icon.png] The transcription factor 7-like 2 (TCF7L2) polymorphism may be associated with focal arteriolar narrowing in Caucasians with hypertension or without diabetes: the ARIC Study.


[PMID 20532014OA-icon.png] The epidemiology of diabetes in Korea: from the economics to genetics.


[PMID 20540670] Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population.


[PMID 20550665OA-icon.png] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.


[PMID 20648057OA-icon.png] Potential role of TCF7L2 gene variants on cardiac sympathetic/parasympathetic activity.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 20957343] Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test.


[PMID 21115178] Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study.


[PMID 21159844] Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.


[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.


[PMID 21283728OA-icon.png] Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.


[PMID 21347282OA-icon.png] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.


[PMID 21349175OA-icon.png] TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes.


[PMID 21384500] Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.


[PMID 21423583OA-icon.png] Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.


[PMID 21437630] Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.


[PMID 21441683OA-icon.png] Screening with OGTT alone or in combination with the Indian diabetes risk score or genotyping of TCF7L2 to detect undiagnosed type 2 diabetes in Asian Indians.


[PMID 21672010OA-icon.png] Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.


[PMID 21834909] A replication study of the IRS1, CAPN10, TCF7L2, and PPARG gene polymorphisms associated with type 2 diabetes in two different populations of Mexico.


[PMID 21898192] Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.


[PMID 21965303] Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway.


[PMID 22377714] Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea.


[PMID 22461567OA-icon.png] Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.


[PMID 22552033] Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain.


[PMID 22583123OA-icon.png] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.

GWAS snp
PMID [PMID 22693455OA-icon.png]
Trait
Title Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Risk Allele T
P-val 4E-21
Odds Ratio 1.2600 None
GWAS snp
PMID [PMID 22581228OA-icon.png]
Trait
Title A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val 2E-14
Odds Ratio None None


[PMID 23014255] Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters


[PMID 23041303] Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population


GET Evidence
rs7903146
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.242188
summary associated with colorectal cancer for the T allele.



[PMID 23193183OA-icon.png] Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study


[PMID 23249316] Genetic susceptibility to type 2 diabetes: a global meta-analysis studying the genetic differences in tunisian populations


[PMID 23029294OA-icon.png] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus


[PMID 23527042OA-icon.png] Replication of type 2 diabetes candidate genes variations in three geographically unrelated Indian population groups


[PMID 23536853OA-icon.png] Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population

GWAS snp
PMID [PMID 23300278OA-icon.png]
Trait Type 2 diabetes
Title Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India.
Risk Allele T
P-val 2E-38
Odds Ratio 1.15 [1.12 - 1.17]


[PMID 23311683OA-icon.png] Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population

GWAS snp
PMID [PMID 23209189OA-icon.png]
Trait Type 2 diabetes
Title Genome-wide association study for type 2 diabetes in indians identifies a new susceptibility locus at 2q21.
Risk Allele T
P-val 1E-35
Odds Ratio 1.51 [1.42-1.62]


[PMID 23577093OA-icon.png] Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India


[PMID 23690305OA-icon.png] Genetic variants and the risk of gestational diabetes mellitus: a systematic review


[PMID 22749234] Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs


[PMID 23188737] TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects


[PMID 23926018] [Study of the association between SNP rs7903146(C/T) in TCF7L2 and metabolic syndrome in Chinese Korean and Han populations from Yanbian]


[PMID 23942764] Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts


[PMID 23942586OA-icon.png] Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymorphism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled trial in a high-cardiovascular-risk population


[PMID 24157263] Polymorphisms of Transcription Factor-7-Like 2 (TCF7L2) gene in Tunisian women with polycystic ovaries syndrome (PCOS)


[PMID 24371822OA-icon.png] IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population


[PMID 24435973] Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population


[PMID 24498581OA-icon.png] Role of the single nucleotide polymorphism rs7903146 of TCF7L2 in inducing nonsense-mediated decay


[PMID 24529562] Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration


[PMID 24574000OA-icon.png] Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients


[PMID 22480428] T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition.


[PMID 22782288OA-icon.png] Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes.


[PMID 22843023] TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.


[PMID 22862926] Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.


[PMID 22872755] Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk.


[PMID 22911383] TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals.


[PMID 22923468OA-icon.png] Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.


[PMID 22936689OA-icon.png] Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses.


[PMID 22996130OA-icon.png] From mice to humans.


[PMID 23010200] Association of TCF7L2 gene polymorphisms with type 2 diabetes mellitus in Han Chinese population: a meta-analysis.


[PMID 23011354OA-icon.png] In vitro scan for enhancers at the TCF7L2 locus.


[PMID 23034957OA-icon.png] TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention.


[PMID 23085767OA-icon.png] Associations between TCF7L2 polymorphisms and risk of breast cancer among Hispanic and non-Hispanic white women: the Breast Cancer Health Disparities Study.


[PMID 23107111] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.


[PMID 23142382] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects.


[PMID 23334806OA-icon.png] Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.


[PMID 23434931OA-icon.png] TCF7L2 variation and proliferative diabetic retinopathy.


[PMID 23458876] ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.


[PMID 23855352] Association of the rs7903146 polymorphism in transcription factor 7-like 2 (TCF7L2) gene with gestational diabetes mellitus: a meta-analysis.


[PMID 24864085] Is TCF7L2 variant associated with non-diabetic chronic kidney disease progression? Results of a family-based study


[PMID 24906949OA-icon.png] Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin


[PMID 24925104OA-icon.png] Clinical and non-targeted metabolomic profiling of homozygous carriers of Transcription Factor 7-like 2 variant rs7903146


[PMID 25058603] Differential transcriptional and post-translational Transcription factor 7-like regulation among nondiabetic individuals and type 2 diabetic patients

GWAS snp
PMID [PMID 24390345OA-icon.png]
Trait Type 2 diabetes
Title Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
Risk Allele T
P-val 1E-14
Odds Ratio 1.37 [1.27-1.48]


[PMID 25185411] Association of rs7903146, rs12255372, and rs290487 polymorphisms in TCF7L2 gene with type 2 diabetes in an Iranian Kurdish ethnic group


[PMID 25224167] Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients

GWAS snp
PMID [PMID 24509480]
Trait Type 2 diabetes
Title Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Risk Allele T
P-val 8E-75
Odds Ratio 1.40 [1.35-1.46]
GWAS snp
PMID [PMID 23945395]
Trait Type 2 diabetes
Title Genome-wide association study identifies three novel loci for type 2 diabetes.
Risk Allele T
P-val 2E-15
Odds Ratio 1.48 [1.34-1.63]