Rs4506565
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs4506565 |
| hapmap | rs4506565 |
| hgdp | rs4506565 |
| ensembl | rs4506565 |
| gopubmed | rs4506565 |
| scholar | rs4506565 |
| rs4506565 | |
| pharmgkb | rs4506565 |
| hgvbaseg2p | rs4506565 |
| medrefsnp | rs4506565 |
| 23andMe | rs4506565 |
| SNP Nexus |
| Gene | TCF7L2 |
| Chromosome | 10 |
| Orientation | plus |
| Position | 114746030 |
| Genotype | Effect |
|---|---|
| rs4506565(A;A) | 1.9x increased risk for type-2 diabetes |
| rs4506565(A;T) | 1.4x increased risk for type-2 diabetes |
| rs4506565(T;T) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs4506565(A;A) | 1.9x increased risk for type-2 diabetes | |
| Rs4506565(A;T) | 1.4x increased risk for type-2 diabetes | |
| Rs4506565(T;T) | normal |
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.36 (CI 1.2-1.54), and for homozygotes, 1.88 (CI 1.56-2.27). [PMID 17554300]
Note: this is one of two SNPs within the TCF7L2 gene that have been reported to be associated with type-2 diabetes, the other being rs7903146. They have approximately equal power to estimate risk for type-2 diabetes, and the results from one correlate 92% of the time with the other. [PMID 17554300]
| ? | (A;A) (A;T) (T;T) |
|---|---|
|
| |
Related to DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
according to omim 125853. See also
| PharmGKB | PA161749010 |
| Name | |
| Annotation | This variant has been reported to be significantly associated with type 2 diabetes in several studies. |
| Gene | TCF7L2 |
| Featue | |
| Evidence | PubMed ID:17554300 |
| Drugs | |
| Diseases | Diabetes Mellitus, Type 2 |
| Curation Level | Curated |
[PMID 20018066] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study
| GWAS snp | |
|---|---|
| PMID | [PMID 20081858] |
| Trait | Fasting glucose-related traits |
| Title | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| Risk Allele | T |
| P-val | 1E-8 |
| Odds Ratio | None None |
