TCF7L2

From SNPedia

These two snps rs12255372 and rs7903146 greatly influence your risk of Type-2 diabetes.

This has been confirmed by

• several researchers ([PMID 16936217] [PMID 16855264] [1] [PMID 16936217])
• Research [[2] [PMID 16936217] shows snps in the gene TCF7L2 significantly increases the risk of Type-2 diabetes.
• Refining the impact of TCF7L2 gene variants on Type-2 diabetes and adaptive evolution [PMID 17206141].
• [3] Carrying two copies of a common variant of TCF7L2 doubles your chances of developing Type-2 diabetes and puts you in a similar risk category to being clinically obese. A common variant of the gene increased the risk of developing diabetes by 50 per cent. Carrying two copies of the variant gene increased the risk two-fold, to nearly 100 per cent. In the population as a whole, the impact of this gene on the risk of developing diabetes is as big as the problem of being clinically obese (having a body mass index over 30).
• Polymorphism in TCF7L2 is associated with reduced insulin secretion in nondiabetic women [PMID 17130514]

This news article summarizes how snps increase the risk

IHOP Information Hyperlinked Over Proteins.

PolyDoms Snap

[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas - related to diabetes